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. 2022 Jul 19:2022:1581958.
doi: 10.1155/2022/1581958. eCollection 2022.

Improved Multiclassification of Schizophrenia Based on Xgboost and Information Fusion for Small Datasets

Wenjing Zhu  1   2 , Shoufeng Shen  3 , Zhijun Zhang  1   2
Affiliations

Improved Multiclassification of Schizophrenia Based on Xgboost and Information Fusion for Small Datasets

Wenjing Zhu et al. Comput Math Methods Med. .

Abstract

To improve the performance in multiclass classification for small datasets, a new approach for schizophrenic classification is proposed in the present study. Firstly, the Xgboost classifier is introduced to discriminate the two subtypes of schizophrenia from health controls by analyzing the functional magnetic resonance imaging (fMRI) data, while the gray matter volume (GMV) and amplitude of low-frequency fluctuations (ALFF) are extracted as the features of classifiers. Then, the D-S combination rule of evidence is used to achieve fusion to determine the basic probability assignment based on the output of different classifiers. Finally, the algorithm is applied to classify 38 healthy controls, 16 deficit schizophrenic patients, and 31 nondeficit schizophrenic patients. 10-folds cross-validation method is used to assess classification performance. The results show the proposed algorithm with a sensitivity of 73.89%, which is higher than other classification algorithms, such as supported vector machine (SVM), logistic regression (LR), K-nearest neighbor (KNN) algorithm, random forest (RF), BP neural network (NN), classification and regression tree (CART), naive Bayes classifier (NB), extreme gradient boosting (Xgboost), and deep neural network (DNN). The accuracy of the fusion algorithm is higher than that of classifier based on the GMV or ALFF in the small datasets. The accuracy rate of the improved multiclassification method based on Xgboost and fusion algorithm is higher than that of other machine learning methods, which can further assist the diagnosis of clinical schizophrenia.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Flow chat of improved multiclassification algorithm.
Figure 2
Figure 2
Flow chat of 10-fold cross-validation.
Figure 3
Figure 3
Results of logistic classifier (GMV).
Figure 4
Figure 4
Results of logistic classifier (ALFF).
Figure 5
Figure 5
Results of SVM with kernel of RBF (GMV).
Figure 6
Figure 6
Results of SVM with kernel of RBF (ALFF).
Figure 7
Figure 7
Results of Xgboost (GMV).
Figure 8
Figure 8
Results of Xgboost (ALFF).
Figure 9
Figure 9
Results of Xgboost (fusion).
Figure 10
Figure 10
Accuracy of different classifiers.
Algorithm 1
Algorithm 1
Greedy algorithm for split finding.
See this image and copyright information in PMC

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