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Review
. 2022 Jul 12:16:781488.
doi: 10.3389/fnins.2022.781488. eCollection 2022.

Transcranial Current Stimulation as a Tool of Neuromodulation of Cognitive Functions in Parkinson's Disease

Ivan V Brak  1   2 , Elena Filimonova  3 , Oleg Zakhariya  4 , Rustam Khasanov  4   5 , Ivan Stepanyan  6   7
Affiliations
Review

Transcranial Current Stimulation as a Tool of Neuromodulation of Cognitive Functions in Parkinson's Disease

Ivan V Brak et al. Front Neurosci. .

Abstract

Decrease in cognitive function is one of the most common causes of poor life quality and early disability in patients with Parkinson's disease (PD). Existing methods of treatment are aimed at both correction of motor and non-motor symptoms. Methods of adjuvant therapy (or complementary therapy) for maintaining cognitive functions in patients with PD are of interest. A promising subject of research in this regard is the method of transcranial electric current stimulation (tES). Here we reviewed the current understanding of the pathogenesis of cognitive impairment in PD and of the effects of transcranial direct current stimulation and transcranial alternating current stimulation on the cognitive function of patients with PD-MCI (Parkinson's Disease-Mild Cognitive Impairment).

Keywords: Parkinson disease (PD); mild cognitive impairment (MCI); transcranial alternating current stimulation (tACS); transcranial direct current stimulation (HD-tDCS); transcranial magnetic stimulation (TMS).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Interaction between the structures of the central nervous system: (A) at normal; (B) with Parkinson’s disease; (C) in the pathogenetic therapy of Parkinson’s disease using tDCS.
FIGURE 2
FIGURE 2
The tDCS mechanism. Shift of membrane excitability when exposed to a weak direct current.
FIGURE 3
FIGURE 3
In-phase and antiphase tACS for modulation of the middle frontal theta rhythm.
See this image and copyright information in PMC

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