Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides
- PMID: 35904065
- DOI: 10.1039/d2cc03202c
Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides
Abstract
The construction of vicinal stereogenic centers via the simultaneous formation of two C-C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.
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