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. 2022 Aug 16;58(66):9282-9285.
doi: 10.1039/d2cc03202c.

Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides

Tingting Xia  1 , Yang Xi  1 , Haojie Ding  1 , Yetong Zhang  1 , Ke Fang  1 , Xianqing Wu  1 , Jingping Qu  1 , Yifeng Chen  1
Affiliations

Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides

Tingting Xia et al. Chem Commun (Camb). .

Abstract

The construction of vicinal stereogenic centers via the simultaneous formation of two C-C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.

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