Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Nov;48(11):1625-1628.
doi: 10.1007/s00134-022-06806-x. Epub 2022 Jul 29.

Evolution of sedation management in the intensive care unit (ICU)

Joanna L Stollings  1   2 , Michelle C Balas  3 , Gerald Chanques  4
Affiliations
Comment

Evolution of sedation management in the intensive care unit (ICU)

Joanna L Stollings et al. Intensive Care Med. 2022 Nov.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
This is timeline of selected landmark trials involved in the evolution of sedation in the ICU. References for this figure are listed from left to right starting at the top in the Electronic Supplementary Material 2. IV, intravenous; SAT, spontaneous awakening trial; SCCM, Society of Critical Care Medicine; SAG, The Clinical Practice Guidelines for the Sustained Use of Sedatives and Analgesics in the Critically Ill Adult; SBT, spontaneous breathing trial; MENDS, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction; SEDCOM, Safety and Efficacy of Dexmedetomidine versus Midazolam; PICS, Post Intensive Care Syndrome; PAD, The Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult ICU Patients; ABCDE, Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility; SOS, Immediate interruption of sedation compared with usual sedation care in critically ill postoperative patients; PADIS, The Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU; ABCDEF, “A” for Assessment, Prevention, and Manage pain; “B” for Both Spontaneous Awakening Trials and Spontaneous Breathing Trials; “C” for Choice of Analgesia and Sedation; “D” for Delirium Assess, Prevent, and Manage; "E" for Early Mobility and Exercise; and “F” for Family Engagement and Empowerment; SPICE 3, Sedation Practice in Intensive Care Evaluation; NONSEDA, No Sedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients; ARDS, Acute Respiratory Distress Syndrome; MENDS 2, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Sepsis
See this image and copyright information in PMC

Comment on

  • Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
    Hughes CG, Mailloux PT, Devlin JW, Swan JT, Sanders RD, Anzueto A, Jackson JC, Hoskins AS, Pun BT, Orun OM, Raman R, Stollings JL, Kiehl AL, Duprey MS, Bui LN, O'Neal HR Jr, Snyder A, Gropper MA, Guntupalli KK, Stashenko GJ, Patel MB, Brummel NE, Girard TD, Dittus RS, Bernard GR, Ely EW, Pandharipande PP; MENDS2 Study Investigators. Hughes CG, et al. N Engl J Med. 2021 Apr 15;384(15):1424-1436. doi: 10.1056/NEJMoa2024922. Epub 2021 Feb 2. N Engl J Med. 2021. PMID: 33528922 Free PMC article. Clinical Trial.

References

    1. Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306. doi: 10.1097/CCM.0b013e3182783b72. - DOI - PubMed
    1. Devlin JW, Skrobik Y, Gelinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825–e873. doi: 10.1097/CCM.0000000000003299. - DOI - PubMed
    1. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, Chalfin DB, Masica MF, Bjerke HS, Coplin WM, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30(1):119–141. doi: 10.1097/00003246-200201000-00020. - DOI - PubMed
    1. Shapiro BA, Warren J, Egol AB, Greenbaum DM, Jacobi J, Nasraway SA, Schein RM, Spevetz A, Stone JR. Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine. Crit Care Med. 1995;23(9):1596–1600. doi: 10.1097/00003246-199509000-00021. - DOI - PubMed
    1. Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Seppelt IM, Webb S, Weisbrodt L, et al. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med. 2012;186(8):724–731. doi: 10.1164/rccm.201203-0522OC. - DOI - PubMed

Substances

LinkOut - more resources