In vitro review of nanoparticles attacking macrophages: Interaction and cell death

Abstract

In recent years, the wide application of nanoparticles (NPs) inevitably leads to environmental pollution and human exposure, and its safety has attracted more and more attention. Since macrophages are the cells most directly exposed to multi-pathway invading NPs in the body, it is necessary to assess of toxic effects of NPs in macrophages, clarify the potential mechanisms of NPs toxicity to improve our understanding about the interaction of NPs with macrophages in vivo, and avoid body damage. Currently, studies on the toxicity of NPs to macrophages are rare and mainly focused on in vitro, so this paper integrated the toxic effect of macrophages exposed to NPs and the macrophages cellular changes following the interaction with NPs, including NPs internalization, ROS production, cytokines alterations, DNA damage and cell death, and further explored the involved mechanisms. This review aims to provide some insights into the further toxicological studies of NPs.

Keywords: Cellular internalization; Cytotoxicity; Macrophages; Nanotoxicity; Toxicity mechanism.