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Editorial
. 2022 Aug;33(8):1435-1437.
doi: 10.1681/ASN.2022060668.

Identifying Antigen-Specific T Cells in ANCA-Associated Vasculitis: A Glimpse of the Future?

Lani Shochet  1   2 , A Richard Kitching  3   2   4
Affiliations
Editorial

Identifying Antigen-Specific T Cells in ANCA-Associated Vasculitis: A Glimpse of the Future?

Lani Shochet et al. J Am Soc Nephrol. 2022 Aug.
No abstract available

Keywords: ANCA; glomerulonephritis; lymphocytes; vasculitis.

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Figures

Figure 1.
Figure 1.
PR3-AAV and antigen-specific T cells. Currently, decisions on treatment duration and determination of relapse in this autoimmune disease are often difficult and are guided by clinical features, assessment of B cell autoimmunity by ANCA, and other investigations (left). The ability to define active autoimmunity more precisely by identifying and phenotyping PR3-specific CD4+ T cells (right) would allow for a more thorough understanding of disease course, paving the way for more precise treatment options, by examining the numbers, phenotyping, and activity of autoreactive T cells. Tfh, T follicular helper cell; Th, T helper cell; Treg, regulatory CD4+ T cell. Figure created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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    1. Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, et al. : Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature 545: 243–247, 2017 - PMC - PubMed
    1. Chen D, McInnis E, Wu E, Stember K, Hogan S, Hu Y, et al. : Immunological interaction of HLA-DPB1 and proteinase 3 in ANCA vasculitis is associated with clinical disease activity [published online ahead of print June 7, 2022]. J Am Soc Nephrol - PMC - PubMed
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    1. Hilhorst M, Arndt F, Joseph Kemna M, Wieczorek S, Donner Y, Wilde B, et al. : HLA-DPB1 as a risk factor for relapse in antineutrophil cytoplasmic antibody-associated vasculitis: A cohort study. Arthritis Rheumatol 68: 1721–1730, 2016 - PubMed

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