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Editorial
. 2022 Aug;33(8):1433-1434.
doi: 10.1681/ASN.2022050557.

Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the Cilium

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Editorial

Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the Cilium

Michael J Caplan. J Am Soc Nephrol. 2022 Aug.
No abstract available

Keywords: IP3 receptor; calcium; cilium; endoplasmic reticulum; polycystic kidney disease; polycystin-2.

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References

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    1. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, et al. : Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33: 129–137, 2003 - PubMed
    1. Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE: Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. eLife 7: e33183, 2018 - PMC - PubMed
    1. Padhy B, Xie J, Wang R, Lin F, Huang C-L: Channel function of polycystin-2 in the endoplasmic reticulum protects against autosomal dominant polycystic kidney disease. JASN 33: 1501–1516, 2022 - PMC - PubMed

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