Transfusion-induced red blood cell alloimmunisation is unhampered in elderly patients

Josine A Oud^{1

2

3}, Dorothea Evers⁴, Masja de Haas^{1

2

5}, Karen M K de Vooght⁶, Daan van de Kerkhof⁷, Nel Som⁸, Nathalie C V Péquériaux⁹, Francisca Hudig¹⁰, Johanna G van der Bom^{1

3}, Jaap Jan Zwaginga^{1

2}

Affiliations

¹ Center for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands.
² Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Department of Haematology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁵ Department of Immunohaematology Diagnostics, Sanquin, Amsterdam, The Netherlands.
⁶ Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.
⁷ Department of Clinical Chemistry and Haematology, Catharina Hospital, Eindhoven, The Netherlands.
⁸ Department of Clinical Chemistry, Amsterdam University Medical Center, VUmc, Amsterdam, The Netherlands.
⁹ Department of Clinical Chemistry and Haematology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
¹⁰ LabWest, Haga Teaching Hospital, The Hague, The Netherlands.

Josine A Oud et al. Br J Haematol. 2022 Oct.

. 2022 Oct;199(2):e1-e4.

doi: 10.1111/bjh.18374. Epub 2022 Jul 29.

¹ Center for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands.
² Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Department of Haematology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁵ Department of Immunohaematology Diagnostics, Sanquin, Amsterdam, The Netherlands.
⁶ Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.
⁷ Department of Clinical Chemistry and Haematology, Catharina Hospital, Eindhoven, The Netherlands.
⁸ Department of Clinical Chemistry, Amsterdam University Medical Center, VUmc, Amsterdam, The Netherlands.
⁹ Department of Clinical Chemistry and Haematology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
¹⁰ LabWest, Haga Teaching Hospital, The Hague, The Netherlands.

No abstract available

References

1. Crooke SN, Ovsyannikova IG, Poland GA, Kennedy RB. Immunosenescence and human vaccine immune responses. Immun Ageing. 2019 Sep;13(16):25. https://doi.org/10.1186/s12979-019-0164-9
1. Pera A, Campos C, López N, Hassouneh F, Alonso C, Tarazona R, et al. Immunosenescence: implications for response to infection and vaccination in older people. Maturitas. 2015 Sep;82(1):50-5. https://doi.org/10.1016/j.maturitas.2015.05.004
1. Ciabattini A, Nardini C, Santoro F, Garagnani P, Franceschi C, Medaglini D. Vaccination in the elderly: the challenge of immune changes with aging. Semin Immunol. 2018 Dec;40:83-94. https://doi.org/10.1016/j.smim.2018.10.010
1. Allen JC, Toapanta FR, Chen W, Tennant SM. Understanding immunosenescence and its impact on vaccination of older adults. Vaccine. 2020 Dec 14;38(52):8264-8272. https://doi.org/10.1016/j.vaccine.2020.11.002
1. Borkent-Raven BA, Janssen MP, Van Der Poel CL, Schaasberg WP, Bonsel GJ, Van Hout BA. The PROTON study: profiles of blood product transfusion recipients in The Netherlands. Vox Sang. 2010;99:54-64. https://doi.org/10.1111/j.1423-0410.2010.01312.x