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. 2022 Nov;26(11):6721-6732.
doi: 10.1007/s00784-022-04631-6. Epub 2022 Jul 29.

Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study

Khalid N Said  1 , Ahmed M Al-Momani  1 , Jassim A Almaseeh  1 , Nadya Marouf  1 , Amer Shatta  1 , Jassim Al-Abdulla  1 , Sahar Alaji  1 , Hanin Daas  2 , Shailaja S Tharupeedikayil  1 , Venkateswara Rao Chinta  3 , Ali Ait Hssain  4 , Mohammad Abusamak  5 , Shiraz Salih  2 , Noha Barhom  2 , Wenji Cai  5 , Mariano Sanz  6 , Faleh Tamimi  7
Affiliations

Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study

Khalid N Said et al. Clin Oral Investig. 2022 Nov.

Abstract

Background: In previous studies, COVID-19 complications were reported to be associated with periodontitis. Accordingly, this study was designed to test the hypothesis that a history of periodontal therapy could be associated with lower risk of COVID-19 complications.

Methods: A case-control study was performed using the medical health records of COVID-19 patients in the State of Qatar between March 2020 and February 2021 and dental records between January 2017 and December 2021. Cases were defined as COVID-19 patients who suffered complications (death, ICU admissions and/or mechanical ventilation); controls were COVID-19 patients who recovered without major complications. Associations between a history of periodontal therapy and COVID-19 complications were analysed using logistic regression models adjusted for demographic and medical factors. Blood parameters were compared using Kruskal-Wallis test.

Results: In total, 1,325 patients were included. Adjusted odds ratio (AOR) analysis revealed that non-treated periodontitis was associated with significant risk of need for mechanical ventilation (AOR = 3.91, 95% CI 1.21-12.57, p = 0.022) compared to periodontally healthy patients, while treated periodontitis was not (AOR = 1.28, 95% CI 0.25-6.58, p = 0.768). Blood analyses revealed that periodontitis patients with a history of periodontal therapy had significantly lower levels of D-dimer and Ferritin than non-treated periodontitis patients.

Conclusion: Among COVID-19 patients with periodontal bone loss, only those that have not received periodontal therapy had higher risk of need for assisted ventilation. COVID-19 patients with a history of periodontal therapy were associated with significantly lower D-dimer levels than those without recent records of periodontal therapy.

Clinical relevance: The fact that patients with treated periodontitis were less likely to suffer COVID-19 complications than non-treated ones further strengthen the hypothesis linking periodontitis to COVID-19 complications and suggests that managing periodontitis could help reduce the risk for COVID-19 complications, although future research is needed to verify this.

Keywords: COVID-19; D-dimer; Periodontal disease; Periodontal therapy; Periodontitis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Box plots of the blood work of COVID-19 patients at admission (initial) comparing patients without periodontitis with those with periodontitis that have received treatment for periodontitis and those that did not receive periodontal treatment. (*) indicates significant differences between groups (p < 0.05). The letter n indicates the number of patients analysed for each parameter and condition
Fig. 2
Fig. 2
Box plots of the blood work of COVID-19 patients before being discharged, comparing patients without periodontitis with those with periodontitis that have received treatment for periodontitis and those that did not receive periodontal treatment. (*) indicates significant differences between groups (p < 0.05). The letter n indicates the number of patients analysed for each parameter and condition
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