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Review
. 2022 Sep;49(9):8871-8882.
doi: 10.1007/s11033-021-07094-2. Epub 2022 Jul 29.

Stearoyl-CoA desaturase 1 as a therapeutic target for cancer: a focus on hepatocellular carcinoma

Mortaza Raeisi  1 , Leila Hassanbeigi  1 , Fatemeh Khalili  1 , Hengameh Kharrati-Shishavan  2 , Mehdi Yousefi  3 , Amir Mehdizadeh  4
Affiliations
Review

Stearoyl-CoA desaturase 1 as a therapeutic target for cancer: a focus on hepatocellular carcinoma

Mortaza Raeisi et al. Mol Biol Rep. 2022 Sep.

Abstract

One of the main characteristics of cancer cells is the alteration in lipid composition, which is associated with a significant monounsaturated fatty acids (MUFAs) enrichment. In addition to their structural functions in newly synthesized membranes in proliferating cancer cells, these fatty acids are involved in tumorigenic signaling. Increased expression and activity of stearoyl CoA desaturase (SCD1), i.e., an enzyme converting saturated fatty acids to Δ9-monounsaturated fatty acids, has been observed in various cancer cells. This increase in expression and activity has also been associated with cancer aggressiveness and poor patient outcome. Previous studies have also indicated the SCD1 involvement in increased cancer cells proliferation, growth, migration, epithelial to mesenchymal transition, metastasis, chemoresistance, and maintenance of cancer stem cells properties. Hence, SCD1 seems to be a player in malignancy development and may be considered a novel therapeutic target in cancers, including hepatocellular carcinoma (HCC). This review study aims to discuss the impact of SCD1 as a major component in lipid signaling in HCC.

Keywords: Chemoresistance; Epithelial-to-mesenchymal transition; Hepatocellular carcinoma; MUFAs; SCD1.

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