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Review
. 2022 Jul 29;22(1):240.
doi: 10.1186/s12935-022-02655-2.

Oncogenic roles of the lncRNA LINC00460 in human cancers

Min Su #  1   2   3   4 , Jinming Tang #  1   2 , Desong Yang  1   2 , Zhining Wu  1   2 , Qianjin Liao  3 , Hui Wang  4 , Yuhang Xiao  5   6 , Wenxiang Wang  7   8
Affiliations
Review

Oncogenic roles of the lncRNA LINC00460 in human cancers

Min Su et al. Cancer Cell Int. .

Abstract

Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation and progression. Long intergenic non-protein coding RNA 460 (LINC00460), a novel cancer-related lncRNA, exhibits abnormal expression and oncogenic function in multiple cancers, and positively correlates with poor clinical characteristics of cancer patients. LINC00460 has also been shown to be a promising biomarker for diagnosis as well as prognostic evaluation in cancer patients. In this review, we briefly summarized recent knowledge on the expression, functional roles, molecular mechanisms, and diagnostic and prognostic values of LINC00460 in human malignancies.

Keywords: Functional role; Human cancer; LINC00460; Long noncoding RNA; Molecular mechanism; Oncogenic function.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Molecular mechanisms and functional roleunderlying LINC00460 in cancer progression
See this image and copyright information in PMC

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References

    1. Lu W, Cao F, Feng L, Song G, Chang Y, Chu Y, et al. LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2. J Hematol Oncol. 2021;14(1):196. doi: 10.1186/s13045-021-01212-0. - DOI - PMC - PubMed
    1. Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, et al. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 2015;47(3):199–208. doi: 10.1038/ng.3192. - DOI - PMC - PubMed
    1. Jiang W, Pan S, Chen X, Wang ZW, Zhu X. The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy. Mol Cancer. 2021;20(1):116. doi: 10.1186/s12943-021-01406-7. - DOI - PMC - PubMed
    1. Su M, Xiao Y, Ma J, Cao D, Zhou Y, Wang H, et al. Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications. J Hematol Oncol. 2018;11(1):118. doi: 10.1186/s13045-018-0663-8. - DOI - PMC - PubMed
    1. Huang Z, Zhou JK, Peng Y, He W, Huang C. The role of long noncoding RNAs in hepatocellular carcinoma. Mol Cancer. 2020;19(1):77. doi: 10.1186/s12943-020-01188-4. - DOI - PMC - PubMed

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