[Development of second tumors in patients with Hodgkin's disease (review of the literature and personal data)]

Abstract

The literature data and the authors' findings on second tumors in patients treated for Hodgkin's disease are analyzed. Most patients who subsequently developed acute leukemia and solid tumors received chemoradiation treatment, while only few of them were exposed to radiation alone. Acute leukemia and solid tumor development is attributed to application of alkylating drugs. Out of 420 patients under study, leukemia was registered in 2 and solid tumors--in 4 cases.