Clonal evolution in adult TCF3::HLF-positive acute lymphoblastic leukemia undergoing stem cell transplantation

Affiliations

¹ Department of Haematology, University Hospitals Birmingham NHS Foundation Trust Sheffield, Birmingham, UK.
² Department of Genetics, Birmingham Women, s NHS Foundation Trust, Sheffield, UK.
³ Department of Haematology, Sheffield Teaching Hospitals, NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
⁴ Department of Haematology, University Hospitals Birmingham NHS Foundation Trust Sheffield, Birmingham, UK. akanell@hotmail.com.
⁵ Department of Haematology, Sheffield Teaching Hospitals, NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK. akanell@hotmail.com.

Maria Z Ahmed et al. Ann Hematol. 2022 Nov.

. 2022 Nov;101(11):2553-2554.

doi: 10.1007/s00277-022-04941-5. Epub 2022 Jul 30.

¹ Department of Haematology, University Hospitals Birmingham NHS Foundation Trust Sheffield, Birmingham, UK.
² Department of Genetics, Birmingham Women, s NHS Foundation Trust, Sheffield, UK.
³ Department of Haematology, Sheffield Teaching Hospitals, NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
⁴ Department of Haematology, University Hospitals Birmingham NHS Foundation Trust Sheffield, Birmingham, UK. akanell@hotmail.com.
⁵ Department of Haematology, Sheffield Teaching Hospitals, NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK. akanell@hotmail.com.

No abstract available

Keywords: B-ALL; CART; SNP array analysis; TCF3::HLF.

References

1. Harvey RC, Mullighan CG, Wang X et al (2010) Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 116(23):4874–4884. https://doi.org/10.1182/blood-2009-08-239681 - DOI - PubMed - PMC
1. Safavi M, Safaei A, Lotfi M (2018) A rare variant of t (17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation. Blood research 53(1):92–94 - DOI
1. Takeda R, Yokoyama K, Ogawa M et al (2019) The first case of elderly TCF3-HLF-positive B-cell acute lymphoblastic leukemia. Leuk Lymphoma 60(11):2821–2824 - DOI
1. Watanabe A, Inukai T, Kagami K et al (2019) Resistance of t (17; 19) acute lymphoblastic leukemia cell lines to multiagents in induction therapy. Cancer Med 8(11):5274–5288 - DOI
1. Zhang X, Inukai T, Hirose K et al (2012) Oncogenic fusion E2A-HLF sensitizes t (17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. Leukemia 26(12):2483–2493 - DOI