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. 2022 Sep 28;107(10):e4098-e4105.
doi: 10.1210/clinem/dgac456.

Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden

Oskar Swartling  1 , Marie Evans  2   3 , Tim Spelman  4 , Wafa Kamal  5   6 , Olle Kämpe  6   7   8 , Michael Mannstadt  9 , Ylva Trolle Lagerros  1   10 , Sigridur Björnsdottir  5   6
Affiliations

Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden

Oskar Swartling et al. J Clin Endocrinol Metab. .

Abstract

Context: Kidney complications may be considerably higher in patients with chronic hypoparathyroidism (hypoPT) treated with activated vitamin D and calcium supplementation.

Objective: We aimed to investigate the risk of chronic kidney disease (CKD), urolithiasis, and hospitalization in patients with chronic hypoPT.

Methods: In this population-based cohort study in Sweden, national registries (Swedish National Patient Register, Swedish Prescribed Drug Register, and Total Population Register, 1997-2018) were used to identify patients with chronic hypoPT and controls matched by sex, age, and county of residence. We determined time to CKD and urolithiasis diagnosis, and incidence rates of hospitalization.

Results: A total of 1562 patients with chronic hypoPT without preexisting CKD and 15 620 controls were included. The risk of developing CKD was higher in patients with chronic hypoPT compared with controls (hazard ratio [HR] 4.45; 95% CI, 3.66-5.41). In people without prior urolithiasis (n = 1810 chronic hypoPT and n = 18 100 controls), the risk of developing urolithiasis was higher in patients with chronic hypoPT (HR 3.55; 95% CI, 2.84-4.44) compared with controls. Patients with chronic hypoPT had higher incidence rates for all-cause hospitalization (49.59; 95% CI, 48.50-50.70, per 100 person-years vs 28.43; 95% CI, 28.15-28.71, respectively) and for CKD (3.46; 95% CI, 3.18-3.76, per 100 person-years vs 0.72; 95% CI, 0.68-0.77, respectively), compared with controls. Men with hypoPT appear to have a higher risk of CKD than women.

Conclusion: Patients with chronic hypoPT had an increased risk of CKD, urolithiasis, and hospitalization compared with controls.

Keywords: chronic kidney disease; epidemiology; hypoparathyroidism; urolithiasis.

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Figures

Figure 1.
Figure 1.
Proportion of individuals without chronic kidney disease in patients with postsurgical chronic hypoparathyroidism (n = 1133) compared with matched controls (n = 11 330).
Figure 2.
Figure 2.
Proportion of individuals without chronic kidney disease among men and women with chronic hypoparathyroidism.
See this image and copyright information in PMC

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