Deciphering the roles of ABCB5 in normal and cancer cells
- PMID: 35907754
- DOI: 10.1016/j.trecan.2022.07.001
Deciphering the roles of ABCB5 in normal and cancer cells
Abstract
ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.
Keywords: ABCB5; melanocyte biology; melanoma.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests No interests are declared.
Similar articles
-
Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9.J Biol Chem. 2024 Feb;300(2):105594. doi: 10.1016/j.jbc.2023.105594. Epub 2023 Dec 23. J Biol Chem. 2024. PMID: 38145744 Free PMC article.
-
The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β.Cancer Drug Resist. 2024 Aug 7;7:29. doi: 10.20517/cdr.2024.56. eCollection 2024. Cancer Drug Resist. 2024. PMID: 39267923 Free PMC article. Review.
-
Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.Mol Pharm. 2014 Oct 6;11(10):3452-62. doi: 10.1021/mp500230b. Epub 2014 Aug 22. Mol Pharm. 2014. PMID: 25115303 Free PMC article.
-
Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma.Mod Pathol. 2012 Aug;25(8):1169-75. doi: 10.1038/modpathol.2012.71. Epub 2012 May 4. Mod Pathol. 2012. PMID: 22555176
-
Multidrug resistance in the chronic lymphoproliferative disorders.Leuk Lymphoma. 2010 Oct;51(10):1793-804. doi: 10.3109/10428194.2010.500434. Leuk Lymphoma. 2010. PMID: 20615085 Review.
Cited by
-
The β Isoform of Human ATP-Binding Cassette B5 Transporter, ABCB5β, Localizes to the Endoplasmic Reticulum.Int J Mol Sci. 2023 Oct 31;24(21):15847. doi: 10.3390/ijms242115847. Int J Mol Sci. 2023. PMID: 37958830 Free PMC article.
-
The Differentiation and Regeneration Potential of ABCB5+ Mesenchymal Stem Cells: A Review and Clinical Perspectives.J Clin Med. 2025 Jan 21;14(3):660. doi: 10.3390/jcm14030660. J Clin Med. 2025. PMID: 39941329 Free PMC article. Review.
-
Establishment of skin cutaneous melanoma prognosis model based on vascular mimicry risk score.Medicine (Baltimore). 2024 Feb 16;103(7):e36679. doi: 10.1097/MD.0000000000036679. Medicine (Baltimore). 2024. PMID: 38363903 Free PMC article.
-
Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine.Int J Mol Sci. 2022 Dec 21;24(1):66. doi: 10.3390/ijms24010066. Int J Mol Sci. 2022. PMID: 36613507 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical