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. 2022 Oct;8(10):795-798.
doi: 10.1016/j.trecan.2022.07.001. Epub 2022 Jul 27.

Deciphering the roles of ABCB5 in normal and cancer cells

Laurent Duvivier  1 , Jean-Pierre Gillet  2
Affiliations

Deciphering the roles of ABCB5 in normal and cancer cells

Laurent Duvivier et al. Trends Cancer. 2022 Oct.

Abstract

ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

Keywords: ABCB5; melanocyte biology; melanoma.

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Declaration of interests No interests are declared.

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