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Comment
. 2022 Aug;12(8):e963.
doi: 10.1002/ctm2.963.

Ferroptosis vulnerability in MYCN-driven neuroblastomas

Shayani Dasgupta  1 , Boyi Gan  1   2
Affiliations
Comment

Ferroptosis vulnerability in MYCN-driven neuroblastomas

Shayani Dasgupta et al. Clin Transl Med. 2022 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Boyi Gan is an inventor of patent applications involving targeting ferroptosis in cancer therapy. Shayani Dasgupta has no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Schematic shows combined inhibition of cystine uptake (by IKE), cysteine de novo synthesis (by propargylglycine [PPG] to block CTH, a key enzyme involved in cysteine synthesis) and GPX4 (by GPX4 CRISPR knockout) depletes intracellular cysteine and GSH availability, and effectively triggers ferroptosis in MYCN‐high neuroblastomas.
See this image and copyright information in PMC

Comment on

  • MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
    Alborzinia H, Flórez AF, Kreth S, Brückner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth J, Büttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wölfl S, Henrich KO, Höfer T, Trumpp A, Westermann F. Alborzinia H, et al. Nat Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. Nat Cancer. 2022. PMID: 35484422 Free PMC article.

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