MicroRNA-204-5p: A pivotal tumor suppressor

Abstract

MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules with a length of approximately 18-25 nt nucleotides that regulate gene expression post-transcriptionally. MiR-204-5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. MiR-204-5p is frequently downregulated in various cancer types and is related to the clinicopathological characteristics and prognosis of cancer patients. So far, many studies have determined that miR-204-5p functions as a tumor suppressor for its extensive and powerful capacity to inhibit tumor proliferation, metastasis, autophagy, and chemoresistance in multiple cancer types. MiR-204-5p appears to be a promising prognostic biomarker and a therapeutic target for human cancers. This review summarized the latest advances on the role of miR-204-5p in human cancers.

Keywords: cancer; gene regulation; miR-204-5p; microRNA; tumor suppressor.

FIGURE 1

MiR‐204‐5p regulates tumorigenesis and progression via various mRNA targets in human cancers. This figure summarizes miR‐204‐5p targets shown in Table 1 of this paper.

FIGURE 2

MiR‐204‐5p regulates multiple pathways in human cancers. (A and B) Gene ontology (GO) Analyses of miR‐204‐5p targets using the online tool Sangerbox (http://vip.sangerbox.com/). (B) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of miR‐204‐5p targets using Sangerbox. (C) Protein–protein interaction (PPI) network was constructed using the mRNA targets of miR‐204‐5p. The web tool (https://cn.string‐db.org/) and the software Cytoscape 3.8.2 were applied to construct the PPI network.