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. 2022 Sep 12;84(9):1261-1264.
doi: 10.1292/jvms.22-0025. Epub 2022 Aug 1.

Novel intrauterine growth retardation model: effects of maternal subtotal nephrectomy on neonates

Shoji Ogawa  1 , Tamaki Yana  1 , Tomohiro Kondo  1 , Toshiya Okada  1
Affiliations

Novel intrauterine growth retardation model: effects of maternal subtotal nephrectomy on neonates

Shoji Ogawa et al. J Vet Med Sci. .

Abstract

Changes in body weight (BW), systolic blood pressure (SBP), and localization of renin in the kidneys of neonates born to normal mothers (C neonates) or to five-sixths (5/6) nephrectomized (2/3 left kidney and right kidney) mothers (Nx neonates) were studied. Maternal 5/6 nephrectomy caused weight loss in neonates but no differences in SBP or renin localization. Culling Nx neonates to a litter of 3 at 1 day after birth resulted in growth catching up with C neonates from 3 weeks old and increases in both SBP and renin-positive cells in neonatal kidney. These findings revealed that maternal 5/6 nephrectomy results in low-birth-weight neonates and that these neonates are at increased risk of metabolic syndrome by catch-up growth.

Keywords: intrauterine growth retardation; maternal subtotal nephrectomy; neonatal rat kidney.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Kidney sections from C (A), Nx (B), and L3 (C) neonates at 4 weeks after birth, stained with anti-rat renin antibody. Renin-positive cells (arrows) are seen in L3 neonates (C), while appear rare in C neonates (A) and Nx neonates (B). In the inset, renin-positive cells (arrows) are seen in the juxtaglomerular apparatus of the three neonates in A–C.
See this image and copyright information in PMC

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