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Randomized Controlled Trial
. 2022 Jul 19:2022:8494868.
doi: 10.1155/2022/8494868. eCollection 2022.

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Qiang Liu  1 , HuiFang Wang  1 , JiHuan Xing  1
Affiliations
Randomized Controlled Trial

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Qiang Liu et al. Biomed Res Int. .

Retraction in

Abstract

The efficacy of tympanum injection and posterior auricular injection in diabetes with sudden hearing loss (SHL) was analyzed. A mobile terminal-based portable pure tone audiometry system and its processing method were established. Based on mobile terminals, a portable pure tone audiometry system including an Android system, pure sound signal generation, pure tone hearing threshold, and client module was established. A masking model and self-adaptive algorithm were used to detect and reduce noise. Besides, the performance of the portable pure tone audiometry system was detected. A total of 46 diabetes patients with SHL diagnosed at the otolaryngology department in BeiChen Hospital between August 2019 and November 2021 were selected as the research objects and randomly divided into the retroauricular group (posterior auricular injection) and the tympanic group (tympanum injection). Each group included 23 cases. All patients received pure tone audiometry (PTA) before and after the treatment. The changes in fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) of the patients were monitored before and after the treatment. Besides, tinnitus loudness visual analog scale (VAS), pain VAS, efficacy, and the incidence of adverse reactions of the patients in two groups were compared. The results indicated that the hear threshold error detected by the medical audiometer and a portable pure tone audiometry system was within 2dB. Before the optimization, there was an error of about 10dB between the hear thresholds detected by the self-adaptive algorithm and a medical audiometer. After the treatment, the hear threshold and average PTA of the patients in the retroauricular and the tympanic groups under different frequencies were both reduced compared with those before the treatment (P < 0.05). The tinnitus VAS score in the retroauricular group was decreased more notably than that in tympanic group (P < 0.01), and the pain VAS score was much lower than that in the tympanic group (P < 0.001). The comparison of FPG, 2hPG, HbA1c, the proportions of cured, significantly effective, effective, ineffective patients, and the total effective rate in the patients in the retroauricular and the tympanic groups before and after the treatment all showed no statistical differences (P > 0.05). The incidence of adverse reactions in tympanic group after the treatment was dramatically higher than that in retroauricular group (P < 0.001). The above results demonstrated that posterior auricular injection showed potential application values in the treatment of SHL with diabetes and established a portable pure tone audiometry system as well as its noise processing method.

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Conflict of interest statement

The authors declare that they have no conflicts of interest regarding this work.

Figures

Figure 1
Figure 1
Overall framework of a mobile terminal-based portable PTA system.
Figure 2
Figure 2
Application process of a portable PTA system.
Figure 3
Figure 3
Process of speech noise detection.
Figure 4
Figure 4
Comparison of PTA results of different audiometry systems.
Figure 5
Figure 5
Comparison of noise detection performance of self-adaptive algorithm before and after optimization.
Figure 6
Figure 6
Comparison of audiometry results of different audiometry systems in different noise conditions.
Figure 7
Figure 7
Comparison of hear thresholds at different frequencies in two groups. (∗ indicated that the comparison with those before treatment showed statistical differences, P < 0.05)
Figure 8
Figure 8
Comparison of the average PTA in the two groups. (∗ indicated that the comparison with those before treatment showed statistical differences, P < 0.05).
Figure 9
Figure 9
Comparison of VAS scores between two groups. (∗∗ indicated that the comparison with retroauricular group showed significant differences, P < 0.01. ∗∗∗ revealed that the comparison with retroauricular demonstrated extremely remarkable differences, P < 0.001)
Figure 10
Figure 10
Comparison of blood glucose indexes in two groups before and after treatment.
Figure 11
Figure 11
Comparison of clinical efficacy between two groups.
Figure 12
Figure 12
Comparison of incidence of adverse reactions of different therapies. (∗ showed the comparison with retroauricular group indicated statistical differences, P < 0.05. ∗∗ revealed that the comparison with retroauricular group demonstrated significant differences, P < 0.01. ∗∗∗ indicated that the comparison with retroauricular group showed extremely notable differences, P < 0.001).
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