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Review
. 2022 Jul 14:13:919670.
doi: 10.3389/fendo.2022.919670. eCollection 2022.

Testicular Sertoli Cell Hormones in Differences in Sex Development

Angela K Lucas-Herald  1 , Rod T Mitchell  2   3
Affiliations
Review

Testicular Sertoli Cell Hormones in Differences in Sex Development

Angela K Lucas-Herald et al. Front Endocrinol (Lausanne). .

Abstract

The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.

Keywords: AMH; Sertoli cell; inhibin B; spermatogenesis; testes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Levels of testosterone, AMH and inhibin B from fetal life to adulthood.
See this image and copyright information in PMC

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