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Editorial
. 2022 Jul 15:4:974798.
doi: 10.3389/fgeed.2022.974798. eCollection 2022.

The promise of gene editing: so close and yet so perilously far

David J Segal  1
Affiliations
Editorial

The promise of gene editing: so close and yet so perilously far

David J Segal. Front Genome Ed. .
No abstract available

Keywords: challenges; costs; editors; in-vivo delivery; innovation; regulations.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abudayyeh O. O., Gootenberg J. S., Essletzbichler P., Han S., Joung J., Belanto J. J., et al. (2017). RNA targeting with CRISPR-Cas13. Nature 550, 280–284. 10.1038/nature24049 - DOI - PMC - PubMed
    1. Ai Y., Liang D., Wilusz J. E. (2022). CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells. Nucleic Acids Res. 50, e65. 10.1093/nar/gkac159 - DOI - PMC - PubMed
    1. Blanchard E. L., Vanover D., Bawage S. S., Tiwari P. M., Rotolo L., Beyersdorf J., et al. (2021). Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents. Nat. Biotechnol. 39, 717–726. 10.1038/s41587-021-00822-w - DOI - PubMed
    1. Challis R. C., Ravindra Kumar S., Chen X., Goertsen D., Coughlin G. M., Hori A. M., et al. (2022). Adeno-associated virus toolkit to target diverse brain cells. Annu. Rev. Neurosci. 45. 10.1146/annurev-neuro-111020-100834 - DOI - PubMed
    1. CRISPR Medicine News (2022). Available at: https://crisprmedicinenews.com/clinical-trials/ (accessed 0619, 2022).

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