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Review
. 2022 Jul 14:13:927883.
doi: 10.3389/fmicb.2022.927883. eCollection 2022.

Efficacy of dietary supplements targeting gut microbiota in the prevention and treatment of gestational diabetes mellitus

Jiayang Wan  1 , Jingmei Ma  1
Affiliations
Review

Efficacy of dietary supplements targeting gut microbiota in the prevention and treatment of gestational diabetes mellitus

Jiayang Wan et al. Front Microbiol. .

Abstract

Gestational diabetes mellitus (GDM) is a kind of metabolic disease occurring during gestation period, which often leads to adverse pregnancy outcomes and seriously harms the health of mothers and infants. The pathogenesis of GDM may be bound up with the abnormal gut microbiota composition in pregnant women. Previous studies have clarified that dietary supplements can regulate the gut microbiota to play a role. Therefore, using dietary supplements, such as probiotics, prebiotics, and synbiotics to target the gut microbiota to regulate the disordered gut microbiota would become a potential method that benefits for preventing and treating GDM. This paper reviews a series of clinical trials in recent years, expounds on the clinical effects of dietary supplements such as probiotics on GDM, and discusses the intervention effects of dietary supplements on GDM related risk factors, including overweight, obesity, and type 2 diabetes mellitus (T2DM). In addition, the relationship of GDM and gut microbiota is also discussed, and the possible mechanisms of dietary supplements are summarized. This review will help to promote the further development of dietary supplements targeting gut microbiota and provide more knowledge support for clinical application in the prevention and treatment of various diseases.

Keywords: gestational diabetes mellitus; gut microbiota; obesity; prebiotics; probiotics; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The mechanisms of action of probiotics, prebiotics, synbiotics, and postbiotics.
Figure 2
Figure 2
The mechanisms of action of probiotic supplements and its role in alleviating the pathology of gestational diabetes mellitus (GDM).
Figure 3
Figure 3
The possible mechanisms of action of probiotics in GDM. LPS, lipopolysaccharide; SCFAs, short-chain fatty acids; GPR 41/43, G-protein-linked receptor 41/43; CB1, cannabinoid receptor 1; ZO-1, zona occludens 1; GLP-1, glucagon like peptide-1; PYY, peptide YY; Treg cells, regulatory T cells; IL-6, interleukin-6; IL-1β, interleukin-1β; and TNF-α, tumor necrosis factor-α.
Figure 4
Figure 4
GDM related risk factors and the main improvement effects of dietary supplements on GDM.
See this image and copyright information in PMC

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