Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 22:2022:6873874.
doi: 10.1155/2022/6873874. eCollection 2022.

Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer's Disease

Biswajit Chakraborty  1 , Nobendu Mukerjee  2   3 , Swastika Maitra  4 , Mehrukh Zehravi  5 , Dattatreya Mukherjee  6 , Arabinda Ghosh  7 , Ehab El Sayed Massoud  8   9   10 , Md Habibur Rahman  11
Affiliations
Review

Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer's Disease

Biswajit Chakraborty et al. Oxid Med Cell Longev. .

Abstract

A high incidence of dementia (60-80%) and a high rate of memory loss are two of the most common symptoms of Alzheimer's disease (AD), which affects the elderly. Researchers have recommended that traditional Chinese medicine (TCM) and Indian medicines can be used to prevent and cure AD. Several studies have linked neuroinflammation linked to amyloid-β (Aβ) deposition in the brain to the pathophysiology of neurodegenerative disorders. As a result, more research is needed to determine the role of inflammation in neurodegeneration. Increased microglial activation, cytokine production, reactive oxygen species (ROS), and nuclear factor kappa B (NF-κB) all play a role in the inflammatory process of AD. This review focuses on the role of neuroinflammation in neuroprotection and the molecular processes used by diverse natural substances, phytochemicals, and herbal formulations in distinct signaling pathways. Currently, researchers are focusing on pharmacologically active natural compounds with the anti-neuroinflammatory potential, making them a possible contender for treating AD. Furthermore, the researchers investigated the limits of past studies on TCM, Indian Ayurveda, and AD. Numerous studies have been carried out to examine the effects of medicinal whole-plant extracts on AD. Clinical investigations have shown that lignans, flavonoids, tannins, polyphenols, triterpenoids, sterols, and alkaloids have anti-inflammatory, antiamyloidogenic, anticholinesterase, and antioxidant properties. This review summarizes information about numerous medicinal plants and isolated compounds used in the treatment of AD and a list of further references.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Disintegrating microtubules in AD (made with BioRender).
Figure 2
Figure 2
The many pathways linked with Alzheimer's disease (AD) therapy are depicted schematically. The decline and increase of the phenomenon are indicated by arrows pointing down and up, respectively (made with BioRender).
Figure 3
Figure 3
(a) Pathology and (b) pathophysiology of AD (made with BioRender).
Figure 4
Figure 4
Curcumin's structure indicates functional groups that could be effective in AAD disease treatment. Curcumin can be used to treat neurodegenerative diseases for a variety of reasons (made with BioRender).
Figure 5
Figure 5
Molecular structure of Withania somnifera.
Figure 6
Figure 6
Effectiveness of Convolvulus pluricaulis on different mental diseases (made with BioRender).
Figure 7
Figure 7
Centella asiatica extract activates the antioxidative defense system in neuronal cells, protecting them from amyloid 1–40-induced neurotoxicity (made with BioRender).
Figure 8
Figure 8
Pharmacological effects of Celastrus paniculatus (made with BioRender).
Figure 9
Figure 9
The transcription factors NF-κB and Nrf2 are among the molecular targets of anti-neuroinflammatory natural product action (made with BioRender).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Brooks L. R. K., Mias G. I. Data-driven analysis of age, sex, and tissue effects on gene expression variability in Alzheimer’s disease. Frontiers in Neuroscience . 2019;13 doi: 10.3389/fnins.2019.00392. - DOI - PMC - PubMed
    1. Alzheimer's Association. 2016 Alzheimer’s disease facts and figures. Alzheimer's & Dementia . 2016;12(4):459–509. doi: 10.1016/j.jalz.2016.03.001. - DOI - PubMed
    1. Feng L., Liao Y. T., He J. C., et al. Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease. BMC Neurology . 2018;18(1):p. 4. doi: 10.1186/s12883-017-1008-x. - DOI - PMC - PubMed
    1. Blackburn J., Zheng Q., Grabowski D. C., et al. Nursing home chain affiliation and its impact on specialty service designation for Alzheimer disease. Inquiry . 2018;55, article 46958018787992 doi: 10.1177/0046958018787992. - DOI - PMC - PubMed
    1. Atri A. Current and future treatments in Alzheimer’s disease. Seminars in Neurology . 2019;39(2):227–240. doi: 10.1055/s-0039-1678581. - DOI - PubMed

MeSH terms