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. 2022 Jul 13:10:941284.
doi: 10.3389/fpubh.2022.941284. eCollection 2022.

Chinese and Global Burdens of Gastrointestinal Cancers From 1990 to 2019

Wangcheng Xie  1 , Tingsong Yang  1 , Jieliang Zuo  1 , Zhilong Ma  2 , Weidi Yu  1 , Zhengyu Hu  1 , Zhenshun Song  1   3
Affiliations

Chinese and Global Burdens of Gastrointestinal Cancers From 1990 to 2019

Wangcheng Xie et al. Front Public Health. .

Abstract

Background: Gastrointestinal (GI) cancers are an important component of the tumor. This study aimed to investigate the burden of six major GI cancers in China and globally from 1990 to 2019.

Methods: We conducted a cross-sectional study based on the Global Burden of Disease Study (GBD) 2019. Indicators on incidence, deaths, disability-adjusted life-years (DALYs), and risk factors for esophageal, stomach, liver, pancreatic, colon and rectum, and gallbladder and biliary tract cancers were collected and analyzed for time trends. The contribution of each cancer and the proportion of cases in China among global cases were further reported.

Results: Global incidence cases, death cases, and DALYs of GI cancers showed an overall ascending trend over the past 30 years, but there was temporal and geographical variation across cancer types. By 2019, colon and rectum cancer had overtaken stomach cancer as the most burdensome GI cancer globally. However, stomach cancer narrowly continued to be the most burdensome GI in China. In addition, the proportion of incidence and death cases of stomach, pancreatic, colon and rectum, and gallbladder and biliary tract cancers among global cases had further increased. It was noteworthy that the burden of liver cancer in China has been alleviated significantly.

Conclusion: GI cancers remain a major public health problem in China and globally. Despite the temporal and geographic diversity of different cancers, targeted primary and secondary prevention are still necessary for the future to face these unknown challenges.

Keywords: death; disability-adjusted life-years; gastrointestinal cancer; incidence; risk factor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The global disease burden of esophageal cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 2
Figure 2
The global disease burden of stomach cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 3
Figure 3
The global disease burden of liver cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 4
Figure 4
The global disease burden of pancreatic cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 5
Figure 5
The global disease burden of colon and rectum cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 6
Figure 6
The global disease burden of the gallbladder and biliary tract cancer in 204 countries and territories. (A) The ASIR in 2019; (B) The relative change in incident cases between 1990 and 2019; (C) The EAPC of ASIR from 1990 to 2019. Outcomes of China were specifically annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
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