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. 2022 Jul 14:9:935991.
doi: 10.3389/fnut.2022.935991. eCollection 2022.

Vitamin C Intake and Ischemic Stroke

Xiaolong Tang  1 , Hanguang Liu  1 , Yuan Xiao  1 , Lei Wu  2 , Peng Shu  3
Affiliations

Vitamin C Intake and Ischemic Stroke

Xiaolong Tang et al. Front Nutr. .

Abstract

Vitamin C is an essential micronutrient with important antioxidant properties. Ischemic stroke is a major public health problem worldwide. Extensive evidence demonstrates that vitamin C has protective effects against cardiovascular disease, and there is a close relationship between vitamin C intake and ischemic stroke risk. Based on the evidence, we conducted this umbrella review to clarify the relationship between vitamin C intake and ischemic stroke risk from four perspectives: cellular mechanisms, animal experiments, clinical trials, and cohort studies.

Keywords: CVD; ischemic stroke; micronutrient; review; vitamin C.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The cellular mechanism by which vitamin C reduces the risk of ischemic stroke. O2: oxygen; eNOS: endothelial nitric oxide synthase; BH3: trihydrobiopterin; BH4: tetrahydrobiopterin; vc: vitamin C; NO: nitric oxide; LDL: low density lipoprotein; OX-LDL: oxidized low density lipoprotein; ICAM-1: intercellular adhesion molecule-1; stroke: stroke; a: vitamin C inhibits low-density lipoprotein oxidation; b: vitamin C reduces trihydrobiopterin to tetrahydrobiopterin; c: Vitamin C reduces the expression of ICAM-1.
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