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Review
. 2022 Jul 27:15:11786388221095223.
doi: 10.1177/11786388221095223. eCollection 2022.

A review of the anti-diabetic potential of saffron

Anis Sani  1 , Ali Tajik  2 , Seiied Sina Seiiedi  3 , Razieh Khadem  2 , Haniye Tootooni  4 , Mohammadhossein Taherynejad  2 , Nasim Sabet Eqlidi  5 , Seyyed Mohammad Matin Alavi Dana  2 , Niloofar Deravi  6
Affiliations
Review

A review of the anti-diabetic potential of saffron

Anis Sani et al. Nutr Metab Insights. .

Abstract

Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated.

Keywords: Crocus sativus L.; Saffron; antioxidant; crocetin; crocin; diabetes mellitus.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Khursheed R, Singh SK, Wadhwa S, et al.. Treatment strategies against diabetes: success so far and challenges ahead. Eur J Pharmacol. 2019;862:172625. - PubMed
    1. Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature. 2019;576:51-60. - PubMed
    1. Khan MA, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of type 2 diabetes – global burden of disease and forecasted trends. J Epidemiol Glob Health. 2020;10:107-111. - PMC - PubMed
    1. Seino Y, Ueno S, Yabe D, Suzuki A. Dietary recommendations for type 2 diabetes patients: Lessons from recent clinical and basic research in Asia. J Diabetes Invest. 2019;10:1405-1407. - PMC - PubMed
    1. Ali A, Ali A, Saeed K, Abbas D, Mehran M, Yousef M, Crocus sativus on serum glucose, insulin and cholesterol levels in healthy male rats. J Med Plants Res. 2010;4:397-402.

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