Clinical Efficacy of Retroauricular Injection of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness with Type 2 Diabetes

Abstract

Background: The etiology of sudden deafness is still unclear. In recent years, people's life rhythm is getting faster and faster. Fatigue, environment, diet, psychology, and other factors have increased the morbidity rate of sudden deafness and improved the quality of life of patients. And work efficiency is greatly affected.

Aims: A study to investigate the clinical efficacy of postauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness with type 2 diabetes.

Materials and methods: Sixty patients with sudden deafness who were treated in our hospital from January 2018 to October 2020 were selected as the subjects of this prospective study and divided into 30 cases each in the comparison group and the observation group according to the random number remainder grouping method. The comparison group was treated conventionally, and the observation group was treated with postauricular injection of methylprednisolone sodium succinate on the basis of the comparison group. Patients in the two groups were observed and compared on the 3rd, 6th, and 9th days after treatment with pure-tone hearing threshold checks and regular monitoring of blood glucose, blood rheology, and other indexes.

Results: On the 7th, 14th, and 30th days after treatment, the pure-tone audiometric thresholds of the two groups were gradually decreased, and the changes in the pure-tone audiometric thresholds in the observation group were greater than those in the control group. After lunch on the 6th day and after lunch on the 9th day, it was lower than that in the control group, and the difference was statistically significant (P < 0.05). 30 days after treatment, the blood viscosity, fibrin, and platelet aggregation rate of the observation group were significantly lower than those of the control group. After treatment, the clinical efficacy rate of the observation group was 96%, which was significantly higher than that of the control group, 80%, and the above differences were statistically significant (P < 0.05).

Conclusion: Treatment with postauricular injection of methylprednisolone sodium succinate has shown better therapeutic recovery in patients with sudden deafness, improved pure-tone hearing threshold, reduced risk of blood glucose elevation, and improved clinical outcomes for patients with sudden deafness, providing some reference for the treatment of patients with sudden deafness.

Figure 1

Comparison of pure-tone audiometry between two groups of patients. In this study, the pure-tone hearing threshold statistics of the two groups of patients were input into Excel software by the first author and the corresponding author, respectively, and the Shapiro-Wilk method of mean ± standard deviation was used for inclusion test. ANOVA was performed between groups to find out. On the 3rd, 6th, and 9th days after treatment, the pure-tone hearing thresholds of the two groups were gradually decreased, and the changes of the pure-tone hearing thresholds in the observation group were greater than those in the control group. The difference is not statistically significant (P > 0.05).

Figure 2

Blood sugar comparison. Statistics for blood glucose comparisons in this study were entered into Excel software by the first and corresponding authors, respectively, and indicators were included in the test using the Shapiro-Wilk method of mean ± standard deviation. And independent sample or paired sample t-test was implemented between groups found. Patients in the observation group showed an increase in blood glucose after lunch on days 3, 6, and 9 compared to the control group, but the difference was not statistically significant (P > 0.05).

Figure 3

Comparison of rheological parameters. In this study, the statistics of the rheological indexes of the two groups of patients were input into Excel software by the first author and the corresponding author, respectively, and the indexes such as blood viscosity, fibrin, and platelet aggregation rate were included in the test using the Shapiro-Wilk method of mean ± standard deviation. Independent samples or paired samples t-tests were performed between groups or within groups to find out. Before treatment, there was no significant difference in the hemorheological indexes between the two groups (P > 0.05). 30 days after treatment, the (a) blood viscosity, (b) fibrin, and (c) platelet aggregation rate in the observation group were significantly lower than those in the control group, with statistical significance (P < 0.05).

Figure 4

Comparison of clinical efficacy. In this study, the statistics of the clinical efficacy of the two groups of patients were input into Excel software by the first author and the corresponding author, respectively, and the data were expressed as integers and found by the chi-square test. After treatment, the clinical efficacy rate of patients in the observation group was 96%, which was significantly higher than that in the control group, 80%, with statistical significance (P < 0.05).