InGaAs based gratings for UV-VIS spectrometer in prospective mRNA vaccine research

Abstract

During the outbreak of the COVID-19 illness, mRNA (messenger RNA) injections proved to be effective vaccination. Among the presently available analytical techniques, UV/VIS spectrophotometry is a trustworthy and practical instrument that may provide information on the chemical components of the vaccine at the molecular level. In this paper, we will present a one-dimensional grating of InGaAs as a prospect grating structure for UV-VIS spectrometer that can be used for mRNA vaccine development. The main parameters and the wavelength region used in mRNA vaccine development lies in the range of 200 nm to 700 nm (UV-VIS Range). The incorporation of new materials that are excellent for cutting-edge semiconductor industry procedures for MEMS manufacture, as well as new optimal parameters, will improve the grating and spectrometer's performance which will enhance the mRNA vaccine development and manufacturing workflows enabled by UV-VIS spectroscopy. Hence we evaluated the feasibility of the materials, Si (Silicon), GaN (Gallium Nitride), InGaAs (Indium Gallium Arsenide) and InP (Indium Phosphide) as a grating material. Reflection spectrum of the proposed structure shows 48% increase compared to the grating made up of Silicon. In order to model wave propagation in one grating unit cell, electromagnetic waves frequency domain interface is used. The periodic constraints of floquet periodicity are used for simulation at both faces of the unit cell. The reflectance of grating with each material as functions of the angle of incidence was plotted. Also we evaluated the effect of grating thickness, groove density, spectral resolution and efficiency over different materials namely Si, GaN, InGaAs and InP. After optimizing geometric parameters, the designed InGaAs based grating achieved a efficiency of 87.45% and can be a reliable prospect for mRNA based vaccine development.

Keywords: COVID-19; Diffraction gratings; MEMS; Optical materials; Spectroscopy; mRNA vaccine.

Fig. 1

Grating in a spectrometer

Fig. 2

Geometry of 1D rectangular grating unit cell and its schematic diagram

Fig. 3

Reflectance with different angle of incidence

Fig.4

Reflectance with grating thickness

Fig. 5

Electric field’s spatial distribution of different materials

Fig. 6

Reflectance with groove density

Fig. 7

Spectral resolution of the grating at different period

Fig. 8

Grating efficiency