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Review
. 2022 Sep 1;37(5):389-393.
doi: 10.1097/HCO.0000000000000973.

Impact of ultrasound enhancing agents on clinical management

Ariane M Fraiche  1   2 , Jordan B Strom  1   2   3
Affiliations
Review

Impact of ultrasound enhancing agents on clinical management

Ariane M Fraiche et al. Curr Opin Cardiol. .

Abstract

Purpose of review: Ultrasound enhancing agents (UEAs), microbubbles which are composed of lipid or albumin shells containing high molecular weight gases with nonlinear acoustic properties in the ultrasound field, are important components of the diagnostic armamentarium in echocardiography. This review highlights the substantial value of UEAs in delineating endocardial border definition and influencing downstream decision-making in cardiovascular ultrasound.

Recent findings: In this article, we review recent updates to the clinical applications of UEAs, special circumstances regarding use, the impact of use on downstream testing and cost-effectiveness, and recommended approaches for optimizing workflow in the echocardiography laboratory with UEAs.

Summary: In multiple studies, UEAs have been identified as a useful tool in echocardiography, improving study accuracy and reader confidence, while reducing downstream testing and procedures and resulting in significant changes in clinical management. Despite their proven efficacy and cost-effectiveness, recent studies have suggested utilization remains low, in part due to perceived concerns and workflow issues that impair uptake. With an increasingly broader list of indications for echocardiography, UEAs will continue to play an important role in the diagnosis and management of patients with cardiovascular and noncardiovascular diseases.

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Conflict of interest statement

Conflicts of Interest: In addition to grant funding above, Dr. Strom also reports consulting for Bracco Diagnostics and General Electric Healthcare, speaker fees from Northwest Imaging Forums, and scientific advisory board work for Edwards Lifesciences and EchoIQ.

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