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. 2022 Nov;167(11):2293-2298.
doi: 10.1007/s00705-022-05550-3. Epub 2022 Aug 1.

Evolutionary analysis of rabies virus isolates from Georgia

Leila Tabatadze #  1 , Ekaterine Gabashvili #  1   2 , Saba Kobakhidze  1   2 , George Lomidze  3 , Jimsher Loladze  4 , Levan Tsitskishvili  5 , Mamuka Kotetishvili  6   7
Affiliations

Evolutionary analysis of rabies virus isolates from Georgia

Leila Tabatadze et al. Arch Virol. 2022 Nov.

Abstract

Genetic relationships between rabies virus (RABV) isolates recovered from dogs, jackals, and cattle in Georgia and their closest relatives were investigated by comparing their nucleoprotein (N) gene sequences. Multiple isolates from dogs and cattle were found to share identical N gene sequences, indicating a risk of dog-to-cattle rabies transmission in Georgia. Exhibiting population-selective sweeps, expansion, and genetic recombination, evolutionary analysis of Georgian RABV isolates (all belonging to the cosmopolitan clade) and isolates from Russia, Turkey, and elsewhere provided further evidence for coinfections with different rabies virus strains and transborder transmission.

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