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Review
. 2022 Oct;90(1):125-137.
doi: 10.1111/prd.12453. Epub 2022 Aug 1.

Influence of epigenetics on periodontitis and peri-implantitis pathogenesis

Lena Larsson  1   2 , Nolan M Kavanagh  3 , Trang V N Nguyen  1 , Rogerio M Castilho  4 , Tord Berglundh  2 , William V Giannobile  5
Affiliations
Free article
Review

Influence of epigenetics on periodontitis and peri-implantitis pathogenesis

Lena Larsson et al. Periodontol 2000. 2022 Oct.
Free article

Abstract

Periodontitis is a disease characterized by tooth-associated microbial biofilms that drive chronic inflammation and destruction of periodontal-supporting tissues. In some individuals, disease progression can lead to tooth loss. A similar condition can occur around dental implants in the form of peri-implantitis. The immune response to bacterial challenges is not only influenced by genetic factors, but also by environmental factors. Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors. Epigenetic modifications have been shown to contribute to the progression of several diseases, including chronic inflammatory diseases like periodontitis and peri-implantitis. This review aims to present the latest findings on epigenetic influences on periodontitis and to discuss potential mechanisms that may influence peri-implantitis, given the paucity of information currently available.

Keywords: biomaterials, dental implants, disease pathogenesis, epigenetics, genetics, periodontal diseases.

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References

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