Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

doi:10.1164/rccm.202204-0671PP

. 2022 Dec 1;206(11):1317-1325.

doi: 10.1164/rccm.202204-0671PP.

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Affiliations

¹ Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
³ Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
⁴ Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
⁵ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, Kentucky.
⁶ Pulmonary and Critical Care Medicine, Department of Medicine, University Medical Center University of Marburg, German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany.
⁷ Hospital Universitario de Caracas, Universidad Central de Venezuela and Centro Médico de Caracas, Caracas, Venezuela.
⁸ Division of Respiratory Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
⁹ University of Michigan Health System, Ann Arbor, Michigan; and.
¹⁰ Cátedra Salud Respiratoria, Universitat de Barcelona; Respiratory Institute, Hospital Clinic, Barcelona; IDIBAPS, CIBERES, Barcelona, Spain.

PMID: 35914087
PMCID: PMC9746870
DOI: 10.1164/rccm.202204-0671PP

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

Bartolome Celli et al. Am J Respir Crit Care Med. 2022.

. 2022 Dec 1;206(11):1317-1325.

doi: 10.1164/rccm.202204-0671PP.

Authors

Affiliations

¹ Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
³ Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
⁴ Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
⁵ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, Kentucky.
⁶ Pulmonary and Critical Care Medicine, Department of Medicine, University Medical Center University of Marburg, German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany.
⁷ Hospital Universitario de Caracas, Universidad Central de Venezuela and Centro Médico de Caracas, Caracas, Venezuela.
⁸ Division of Respiratory Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
⁹ University of Michigan Health System, Ann Arbor, Michigan; and.
¹⁰ Cátedra Salud Respiratoria, Universitat de Barcelona; Respiratory Institute, Hospital Clinic, Barcelona; IDIBAPS, CIBERES, Barcelona, Spain.

PMID: 35914087
PMCID: PMC9746870
DOI: 10.1164/rccm.202204-0671PP

No abstract available

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Figures

**Figure 1.**
Chronic obstructive pulmonary disease (COPD) results from an interaction between genetic predisposition of some individuals with different causative agents over time. It goes through a period (pre-COPD) where the operational threshold that is used to define airflow limitation has not been reached, but symptoms, structural abnormalities detectable with imaging, or functional dysfunction detectable with lung function testing may identify individuals at higher risk of COPD development. Finally, a full-blown spirometrically detectable phase is reached either at young (<50 yr) or older (⩾50 yr) age. AAT = alpha-1-antitrypsin deficiency; PRISM = preserved ratio impaired spirometry.

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Comment in

Chronic Obstructive Pulmonary Disease Definition: Is It Time to Incorporate the Concept of Failure of Lung Regeneration?
Confalonieri M, Braga L, Salton F, Ruaro B, Confalonieri P. Confalonieri M, et al. Am J Respir Crit Care Med. 2023 Feb 1;207(3):366-367. doi: 10.1164/rccm.202208-1508LE. Am J Respir Crit Care Med. 2023. PMID: 36174210 Free PMC article. No abstract available.
Definition of Chronic Obstructive Pulmonary Disease: Occupational Environmental Contribution.
Harber P. Harber P. Am J Respir Crit Care Med. 2023 Feb 1;207(3):366. doi: 10.1164/rccm.202208-1496LE. Am J Respir Crit Care Med. 2023. PMID: 36174213 Free PMC article. No abstract available.

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References

1. Posterior analytics II https://plato.stanford.edu/entries/aristotle-metaphysics/#SubsDefi.
1. Locke JE. 1997. Penguin Books.
1. Scadding JG. Essentialism and nominalism in medicine: logic of diagnosis in disease terminology. Lancet . 1996;348:594–596. - PubMed
1. Pearce JM. Disease, diagnosis or syndrome? Pract Neurol . 2011;11:91–97. - PubMed
1. Livingstone-Banks J. The case for a meta-nosological investigation of pragmatic disease definition and classification. J Eval Clin Pract . 2018;24:1013–1018. - PubMed

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[1] Posterior analytics II https://plato.stanford.edu/entries/aristotle-metaphysics/#SubsDefi.

[2] Posterior analytics II https://plato.stanford.edu/entries/aristotle-metaphysics/#SubsDefi.

[3] Locke JE. 1997. Penguin Books.

[4] Locke JE. 1997. Penguin Books.

[5] Scadding JG. Essentialism and nominalism in medicine: logic of diagnosis in disease terminology. Lancet . 1996;348:594–596. - PubMed

[6] Scadding JG. Essentialism and nominalism in medicine: logic of diagnosis in disease terminology. Lancet . 1996;348:594–596. - PubMed

[7] Pearce JM. Disease, diagnosis or syndrome? Pract Neurol . 2011;11:91–97. - PubMed

[8] Pearce JM. Disease, diagnosis or syndrome? Pract Neurol . 2011;11:91–97. - PubMed

[9] Livingstone-Banks J. The case for a meta-nosological investigation of pragmatic disease definition and classification. J Eval Clin Pract . 2018;24:1013–1018. - PubMed

[10] Livingstone-Banks J. The case for a meta-nosological investigation of pragmatic disease definition and classification. J Eval Clin Pract . 2018;24:1013–1018. - PubMed

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Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

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Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision

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