Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Nov;47(11):906-908.
doi: 10.1016/j.tibs.2022.07.004. Epub 2022 Jul 29.

A new path for terpenoid biosynthesis

Vincent Courdavault  1 , Nicolas Papon  2
Affiliations
Comment

A new path for terpenoid biosynthesis

Vincent Courdavault et al. Trends Biochem Sci. 2022 Nov.

Abstract

Triterpenes are C30 organic compounds abundantly found in all living organisms. Although previously believed to be exclusively produced from squalene or oxidosqualene, a recent report by Tao and colleagues describes a new triterpene biosynthetic route involving the cyclization of the precursor hexaprenyl diphosphate (HexPP) by unprecedented bifunctional terpene synthase (TS) enzymes.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • Discovery of non-squalene triterpenes.
    Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat JS, Liu T. Tao H, et al. Nature. 2022 Jun;606(7913):414-419. doi: 10.1038/s41586-022-04773-3. Epub 2022 Jun 1. Nature. 2022. PMID: 35650436 Free PMC article.

Publication types

LinkOut - more resources