Reply to 'Lactate as a major myokine and exerkine'

Lisa S Chow¹, Robert E Gerszten², Joan M Taylor³, Bente K Pedersen⁴, Henriette van Praag⁵, Scott Trappe⁶, Mark A Febbraio⁷, Zorina S Galis⁸, Yunling Gao⁸, Jacob M Haus⁹, Ian R Lanza¹⁰, Carl J Lavie¹¹, Chih-Hao Lee¹², Alejandro Lucia^{13

14

15}, Cedric Moro^{16

17}, Ambarish Pandey¹⁸, Jeremy M Robbins², Kristin I Stanford¹⁹, Alice E Thackray²⁰, Saul Villeda²¹, Matthew J Watt²², Ashley Xia²³, Juleen R Zierath^{24

25}, Bret H Goodpaster²⁶, Michael Snyder²⁷

Affiliations

¹ Division of Diabetes Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA. chow0007@umn.edu.
² Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
³ Department of Pathology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
⁴ Centre of Inflammation and Metabolism/Centre for PA Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁵ Stiles-Nicholson Brain institute and Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.
⁶ Human Performance Laboratory, Ball State University, Muncie, IN, USA.
⁷ Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
⁸ Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁹ School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
¹¹ Division of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University of Queensland School of Medicine, New Orleans, LA, USA.
¹² Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
¹³ Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
¹⁴ Research Institute Hospital 12 de Octubre ('imas12'), Madrid, Spain.
¹⁵ CIBER en Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
¹⁶ Institute of Metabolic and Cardiovascular Diseases, Team MetaDiab, Inserm UMR1297, Toulouse, France.
¹⁷ Toulouse III University - Paul Sabatier (UPS), Toulouse, France.
¹⁸ Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
¹⁹ Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.
²⁰ National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
²¹ Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
²² Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
²³ Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
²⁴ Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
²⁵ Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
²⁶ Translational Research Institute, AdventHealth, Orlando, FL, USA. bret.goodpaster@adventhealth.com.
²⁷ Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.

PMID: 35915255
DOI: 10.1038/s41574-022-00726-y

Comment

Reply to 'Lactate as a major myokine and exerkine'

Lisa S Chow et al. Nat Rev Endocrinol. 2022 Nov.

. 2022 Nov;18(11):713.

doi: 10.1038/s41574-022-00726-y.

Authors

Affiliations

¹ Division of Diabetes Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA. chow0007@umn.edu.
² Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
³ Department of Pathology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
⁴ Centre of Inflammation and Metabolism/Centre for PA Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁵ Stiles-Nicholson Brain institute and Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.
⁶ Human Performance Laboratory, Ball State University, Muncie, IN, USA.
⁷ Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
⁸ Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁹ School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
¹¹ Division of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University of Queensland School of Medicine, New Orleans, LA, USA.
¹² Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
¹³ Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
¹⁴ Research Institute Hospital 12 de Octubre ('imas12'), Madrid, Spain.
¹⁵ CIBER en Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
¹⁶ Institute of Metabolic and Cardiovascular Diseases, Team MetaDiab, Inserm UMR1297, Toulouse, France.
¹⁷ Toulouse III University - Paul Sabatier (UPS), Toulouse, France.
¹⁸ Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
¹⁹ Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.
²⁰ National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
²¹ Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
²² Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
²³ Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
²⁴ Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
²⁵ Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
²⁶ Translational Research Institute, AdventHealth, Orlando, FL, USA. bret.goodpaster@adventhealth.com.
²⁷ Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.

PMID: 35915255
DOI: 10.1038/s41574-022-00726-y

No abstract available

PubMed Disclaimer

Comment on

Exerkines in health, resilience and disease.
Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder MP. Chow LS, et al. Nat Rev Endocrinol. 2022 May;18(5):273-289. doi: 10.1038/s41574-022-00641-2. Epub 2022 Mar 18. Nat Rev Endocrinol. 2022. PMID: 35304603 Free PMC article. Review.
Lactate as a major myokine and exerkine.
Brooks GA, Osmond AD, Arevalo JA, Curl CC, Duong JJ, Horning MA, Moreno Santillan DD, Leija RG. Brooks GA, et al. Nat Rev Endocrinol. 2022 Nov;18(11):712. doi: 10.1038/s41574-022-00724-0. Nat Rev Endocrinol. 2022. PMID: 35915256 No abstract available.

References

1. Chow, L. S. et al. Exerkines in health, resilience and disease. Nat. Rev. Endocrinol. 18, 273–289 (2022). - DOI
1. Brooks, G. A. et al. Lactate as a major myokine and exerkine. Nat. Rev. Endocrinol. https://doi.org/10.1038/s41574-022-00724-0 (2022). - DOI - PubMed
1. Nalbandian, M. & Takeda, M. Lactate as a signaling molecule that regulates exercise-induced adaptations. Biology (Basel) 5, 1–12 (2016).
1. Willkomm, L. et al. Lactate regulates myogenesis in C2C12 myoblasts in vitro. Stem Cell Res. 12, 742–753 (2014). - DOI
1. Takahashi, H. et al. TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat. Metab. 1, 291–303 (2019). - DOI

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Reply to 'Lactate as a major myokine and exerkine'

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