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Comment
. 2022 Nov;18(11):712.
doi: 10.1038/s41574-022-00724-0.

Lactate as a major myokine and exerkine

George A Brooks  1 , Adam D Osmond  2 , Jose A Arevalo  2 , Casey C Curl  2 , Justin J Duong  2 , Michael A Horning  2 , Diana D Moreno Santillan  2 , Robert G Leija  2
Affiliations
Free article
Comment

Lactate as a major myokine and exerkine

George A Brooks et al. Nat Rev Endocrinol. 2022 Nov.
Free article
No abstract available

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  • Reply to 'Lactate as a major myokine and exerkine'.
    Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder M. Chow LS, et al. Nat Rev Endocrinol. 2022 Nov;18(11):713. doi: 10.1038/s41574-022-00726-y. Nat Rev Endocrinol. 2022. PMID: 35915255 No abstract available.

Comment on

  • Exerkines in health, resilience and disease.
    Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder MP. Chow LS, et al. Nat Rev Endocrinol. 2022 May;18(5):273-289. doi: 10.1038/s41574-022-00641-2. Epub 2022 Mar 18. Nat Rev Endocrinol. 2022. PMID: 35304603 Free PMC article. Review.

References

    1. Chow, L. S. et al. Exerkines in health, resilience and disease. Nat. Rev. Endocrinol. 18, 273–289 (2022). - DOI
    1. Brooks, G. A. The Science and Translation of Lactate Shuttle Theory. Cell Metab. 27, 757–785 (2018). - DOI
    1. Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115–124 (1999). - DOI
    1. Hashimoto, T., Hussien, R., Oommen, S., Gohil, K. & Brooks, G. A. Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis. FASEB J. 21, 2602–2612 (2007). - DOI
    1. Hunt, T. K., Aslam, R., Hussain, Z. & Beckert, S. Lactate, with oxygen, incites angiogenesis. Adv. Exp. Med. Biol. 614, 73–80 (2008). - DOI