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. 2022 Sep;65(5):395-405.
doi: 10.5468/ogs.22146. Epub 2022 Aug 2.

Sentinel lymph node biopsy in high-risk endometrial cancer: performance, outcomes, and future avenues

Yoo-Na Kim  1 , Young Tae Kim  1
Affiliations

Sentinel lymph node biopsy in high-risk endometrial cancer: performance, outcomes, and future avenues

Yoo-Na Kim et al. Obstet Gynecol Sci. 2022 Sep.

Abstract

Endometrial cancer is the second most common gynecological malignancy worldwide, with an overall favorable prognosis. However, a subgroup of patients has a high risk of recurrence and poor prognosis. This review summarizes recently published articles that examined sentinel lymph node (SLN) biopsy in patients with high-risk endometrial cancer. We focused on the performance and outcomes of SLN biopsy, and examined potential methods for improving the management of this high-risk subset. Few studies have examined the long-term outcomes of SLN in patients with high-risk endometrial cancer. Thus, we reviewed recently published retrospective studies that have adopted statistical techniques, such as inverse probability weighting or propensity score matching, to examine the outcome of SLN biopsy compared to conventional lymphadenectomy. Potential avenues for future research to fine-tune decision making for this patient subgroup were also discussed.

Keywords: Endometrial cancer; Sentinel lymph node biopsy.

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Conflict of interest statement

Conflict of interest

There is no conflict of interest in this research. Young Tae Kim has been an Editorial Board of Obstetrics & Gynecology Science; however, he was not involved in the peer reviewer selection, evaluation, or decision process of this article. Otherwise, no other potential conflicts of interest relevant to this article were reported.

References

    1. Abu-Rustum NR. Sentinel lymph node mapping for endometrial cancer: a modern approach to surgical staging. J Natl Compr Canc Netw. 2014;12:288–97. - PubMed
    1. Burke TW, Levenback C, Tornos C, Morris M, Wharton JT, Gershenson DM. Intraabdominal lymphatic mapping to direct selective pelvic and paraaortic lymphadenectomy in women with high-risk endometrial cancer: results of a pilot study. Gynecologic Oncology. 1996;62:169–73. - PubMed
    1. Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, et al. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study. Lancet Oncology. 2017;18:384–92. - PubMed
    1. Ballester M, Dubernard G, Lécuru F, Heitz D, Mathevet P, Marret H, et al. Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO) Lancet Oncology. 2011;12:469–76. - PubMed
    1. Geppert B, Lönnerfors C, Bollino M, Persson J. Sentinel lymph node biopsy in endometrial cancer-feasibility, safety and lymphatic complications. Gynecol Oncol. 2018;148:491–8. - PubMed