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. 2022 Nov;65(6):487-501.
doi: 10.5468/ogs.22060. Epub 2022 Aug 2.

COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data

Ki Hoon Ahn  1 , Hae-In Kim  1   2   3 , Kwang-Sig Lee  3 , Ju Sun Heo  4 , Ho-Yeon Kim  1 , Geum-Joon Cho  1 , Soon-Cheol Hong  1 , Min-Jeong Oh  1 , Hae-Joong Kim  1
Affiliations

COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data

Ki Hoon Ahn et al. Obstet Gynecol Sci. 2022 Nov.

Abstract

Objective: This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.

Methods: Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.

Results: The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.

Conclusion: To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.

Keywords: COVID-19; Infant, newborn; Pregnancy; Pregnancy outcome; Vaccination.

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Conflict of interest statement

Conflict of interest

No potential conflict of interest relevant to this article was reported. Ki Hoon Ahn and Geum-Joon Cho have been an Editorial Board of Obstetrics & Gynecology Science; however, they are not involved in the peer reviewer selection, evaluation, or decision process of this article. Otherwise, no other potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Flowchart of inclusion of women based on pregnancy and COVID-19 status. COVID-19, coronavirus disease 2019.
See this image and copyright information in PMC

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References

    1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–69. - PMC - PubMed
    1. Yuen KS, Ye ZW, Fung SY, Chan CP, Jin DY. SARS-CoV-2 and COVID-19: the most important research questions. Cell Biosci. 2020;10:40. - PMC - PubMed
    1. Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al. Clinical features and treatment of COVID-19 patients in northeast Chongqing. J Med Virol. 2020;92:797–806. - PMC - PubMed
    1. Munn MB, Groome LJ, Atterbury JL, Baker SL, Hoff C. Pneumonia as a complication of pregnancy. J Matern Fetal Med. 1999;8:151–4. - PubMed
    1. Goodnight WH, Soper DE. Pneumonia in pregnancy. Crit Care Med. 2005;33(10 Suppl):S390–7. - PubMed