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Review
. 2022 Jul;20(3):281-290.
doi: 10.5217/ir.2021.00169. Epub 2022 Jul 26.

Endoscopic diagnosis and treatment of early colorectal cancer

Seung Wook Hong  1 , Jeong-Sik Byeon  1
Affiliations
Review

Endoscopic diagnosis and treatment of early colorectal cancer

Seung Wook Hong et al. Intest Res. 2022 Jul.

Abstract

Early colorectal cancer refers to cancer in the colorectum that is confined to the mucosa or submucosa and does not invade the muscularis propria, irrespective of lymph node or distant metastasis. As the number of persons undergoing screening colonoscopy increases, the proportion of patients diagnosed with precancerous colorectal lesions and early colorectal cancer also increases. In the last decade, innovative optical technologies for endoscopic diagnosis have been introduced and endoscopic treatment techniques such as endoscopic submucosal dissection have provided major breakthroughs in the management of early colorectal cancer. With these remarkable developments, endoscopic treatment has established itself as an alternative to surgical resection in the treatment of early colorectal cancer. This review will discuss the endoscopic diagnosis and treatment of early colorectal cancer. Furthermore, the unmet needs in this field and the latest research addressing those issues will be summarized.

Keywords: Colorectal neoplasms; Diagnosis; Endoscopy; Review; Therapeutics.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Management algorithm of colorectal polyp according to morphology and estimated depth of invasion. JNET, Japan Narrow-Band Imaging (NBI) Expert Team.
See this image and copyright information in PMC

References

    1. Zauber AG, Winawer SJ, O’Brien MJ, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366:687–696. - PMC - PubMed
    1. Shaukat A, Mongin SJ, Geisser MS, et al. Long-term mortality after screening for colorectal cancer. N Engl J Med. 2013;369:1106–1114. - PubMed
    1. Pilonis ND, Bugajski M, Wieszczy P, et al. Long-term colorectal cancer incidence and mortality after a single negative screening colonoscopy. Ann Intern Med. 2020;173:81–91. - PubMed
    1. Tung SY, Wu CS, Su MY. Magnifying colonoscopy in differentiating neoplastic from nonneoplastic colorectal lesions. Am J Gastroenterol. 2001;96:2628–2632. - PubMed
    1. Tamura S, Ookawauchi K, Onishi S, et al. The usefulness of magnifying chromoendoscopy: pit pattern diagnosis can predict histopathological diagnosis precisely. Am J Gastroenterol. 2002;97:2934–2935. - PubMed