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Review
. 2022 Oct;59(10):6260-6280.
doi: 10.1007/s12035-022-02966-5. Epub 2022 Aug 2.

A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders

Sara Abdolahi  1 , Ameneh Zare-Chahoki  2 , Farshid Noorbakhsh  3 , Ali Gorji  4   5   6   7
Affiliations
Review

A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders

Sara Abdolahi et al. Mol Neurobiol. 2022 Oct.

Abstract

Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies.

Keywords: BDNF; Brain; CNS; NT3; Neurotrophic Factors; Psychological Disorders.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The interaction between various microRNAs and neurotrophins in different neuropsychological disorders
See this image and copyright information in PMC

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