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. 2022 Aug 1;5(8):e2224897.
doi: 10.1001/jamanetworkopen.2022.24897.

Cancer Incidence Among Adults With HIV in a Population-Based Cohort in Korea

Boyoung Park  1 , Kyoung Hwan Ahn  1 , Yunsu Choi  1 , Jung Ho Kim  2 , Hye Seong  3 , Youn Jeong Kim  4 , Jun Young Choi  2 , Joon Young Song  3 , Eunjung Lee  4 , Yoon Hee Jun  5 , Young Kyung Yoon  3 , Won Suk Choi  3 , Myungsun Lee  6 , Jaehyun Seong  6 , Shin-Woo Kim  7
Affiliations

Cancer Incidence Among Adults With HIV in a Population-Based Cohort in Korea

Boyoung Park et al. JAMA Netw Open. .

Erratum in

  • Error in Affiliations.
    [No authors listed] [No authors listed] JAMA Netw Open. 2022 Oct 3;5(10):e2238976. doi: 10.1001/jamanetworkopen.2022.38976. JAMA Netw Open. 2022. PMID: 36215076 Free PMC article. No abstract available.

Abstract

Importance: In combination with a decreased risk of AIDS-defining cancers and improved survival of people infected with HIV, the burden of non-AIDS-defining cancer has increased markedly. Although a substantial number of studies have measured the cancer risk among people with HIV in developed countries, little research has been conducted on the risk of cancer in HIV-infected people in Asia.

Objective: To examine the cancer incidence and the estimated risk of cancer among people in Korea infected with HIV compared with the general population.

Design, setting, and participants: This retrospective cohort study evaluated patients without cancer newly diagnosed with HIV from January 1, 2006, to December 31, 2018, using a nationwide population-based claims database embedded in the National Health Insurance Service database. Data were analyzed between December 6, 2021, and February 28, 2022.

Exposures: Infection with HIV.

Main outcomes and measures: Cancer incidence and standardized incidence rate (SIR) through indirect standardization.

Results: A total of 11 552 individuals without cancer (10 444 male [90.4%]; mean [SD] age, 39.9 [11.2] years) diagnosed with HIV were identified. The SIR for all cancers was 1.68 (95% CI, 1.50-1.87) in men and 1.26 (95% CI, 0.89-1.64) in women. In men, the highest SIRs were for Kaposi sarcoma (SIR, 349.10; 95% CI, 196.10-502.20) and anal cancer (SIR, 104.20; 95% CI, 55.56-149.90). The incidence of non-Hodgkin lymphoma (SIR, 15.62; 95% CI, 11.85-19.39), Hodgkin lymphoma (SIR, 16.67; 95% CI, 4.32-29.02), and oropharyngeal cancer (SIR, 2.97; 95% CI, 1.36-4.58) in men infected with HIV was higher than in the general population. In women infected with HIV, an increased incidence of cervical cancer (SIR, 4.98; 95% CI, 1.29-8.66) and non-Hodgkin lymphoma (SIR, 11.78; 95% CI, 2.35-21.21) compared with the general population was observed. The SIR of thyroid cancer in patients with HIV was lower than in the general population in both men (SIR, 0.63; 95% CI, 0.27-0.99) and women (SIR, 0.48; 95% CI, 0.06-0.90).

Conclusions and relevance: In this cohort study, cancer risks, especially AIDS-defining cancer and virus-related cancer, were elevated in people with HIV. Efforts for cancer prevention, screening, and better accessibility to medical care in HIV-infected people are warranted.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Proportion of AIDS-Defining Cancer Expressed in Years Since HIV Diagnosis
See this image and copyright information in PMC

References

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