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. 2022 Oct 1;26(4):293-297.
doi: 10.1097/LGT.0000000000000688. Epub 2022 Aug 3.

Conservative Treatment for Cervical Adenocarcinoma In Situ: Long-Term Results

Ermelinda Monti  1 , Edgardo Somigliana, Daniela Alberico  1 , Veronica Boero  1 , Maria Iorio  1 , Eugenia Di Loreto  1 , Andrea Dell'acqua  1 , Carlo Antonio Liverani  2
Affiliations

Conservative Treatment for Cervical Adenocarcinoma In Situ: Long-Term Results

Ermelinda Monti et al. J Low Genit Tract Dis. .

Abstract

Objective: This study aimed to evaluate the effectiveness of conservative treatment for cervical adenocarcinoma in situ (AIS).

Materials and methods: This is a retrospective study on women with histologically confirmed AIS on cervical loop electrosurgical excision procedure specimen, treated conservatively between 2008 and 2020 in our center, Ospedale Maggiore Policlinico, Milan. The main outcome investigated was the risk of recurrence defined as a subsequent finding of recurrent AIS or invasive adenocarcinoma in a long-term follow-up. The disease-free survival curve was computed using the Kaplan-Meyer method. All patients underwent colposcopy with endocervical curettage and cytology every 6 months for the first 2 years after initial surgery and then annual cytology.

Results: Thirty women, aged 26 to 51 years, with histologically proven AIS on excisional specimen with negative margins, negative apex, and negative endocervical curettage were included. The median follow-up was 5.4 years. One woman had a recurrence of AIS after 8 years of follow-up and underwent total hysterectomy. No invasive cervical disease was detected during surveillance.

Conclusions: Women with cervical AIS can be managed conservatively by an excisional procedure, provided that the margins are free and a close and long-term follow-up is guaranteed.

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Conflict of interest statement

The authors have declared they have no conflicts of interest.

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