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. 2022 Nov:128:106044.
doi: 10.1016/j.bioorg.2022.106044. Epub 2022 Jul 28.

Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

Srinivas Samala  1 , Woojeong Lim  1 , Dong Kyun You  1 , Kang Mun Lee  1 , Hongil Jo  2 , Kang Min Ok  2 , Jongmin Park  3 , Chang-Hee Lee  4
Affiliations

Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

Srinivas Samala et al. Bioorg Chem. 2022 Nov.

Abstract

Novel bipyridine-based heterocyclic building block, 3,10-dichloro-benzo[f][1,10]phenanthroline and its Ruthenium(II) complex have been synthesized and fully characterized. The synthesized Ru(II)-complex is highly luminescent displaying emission at 590 nm with quantum yield of ∼0.8 in methanol. Ru(II) complex showed photocytotoxicity upon 400 nm blue light irradiation. Mechanistic study revealed that photoactivated Ru(II) complex generates reactive radical species which can damage the protein inside the cells and induce cell death even with short irradiation time.

Keywords: Phenanthroline; Photo-induced cytotoxicity; Reactive radical species; Ruthenium complex; π-extension.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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