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Comment
. 2022 Aug 2;7(1):262.
doi: 10.1038/s41392-022-01113-9.

Ketogenic diet: new avenues to overcome colorectal cancer

Yuancai Xiang  1   2 , Meng Wang  1 , Hongming Miao  3   4
Affiliations
Comment

Ketogenic diet: new avenues to overcome colorectal cancer

Yuancai Xiang et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. Hongming Miao is the editorial board member of Signal Transduction and Targeted Therapy, but he has not been involved in the process of the manuscript handling.

Figures

Fig. 1
Fig. 1
Schematic illustration of the molecular mechanisms underlying KD-mediated suppression in CRC growth. During a ketogenic diet, abundant ketone bodies, especially BHB, were produced in the liver and were transferred to colorectum via blood circulation. Once the concentration of BHB elevated around colorectal tumor cells, it binds to Hcar2, a G-protein-coupled receptors, and activation Hopx expression, thereby inhibiting cell proliferation and tumorigenesis through suppressing proliferative pathway, such as cell cycle. In addition, multiple combination treatment based on KD demonstrated additive effects on the suppression of CRC, such as the combination with glucose restriction, histone deacetylases inhibitors, and DNA methylation inhibitor. BHB: β-hydroxybutyrate; Hcar2: hydroxyl-carboxylic receptor 2; α, β, γ: G-protein subunits; Hopx: homeobox only protein homeobox; HDAC: histone deacetylases
See this image and copyright information in PMC

Comment on

  • β-Hydroxybutyrate suppresses colorectal cancer.
    Dmitrieva-Posocco O, Wong AC, Lundgren P, Golos AM, Descamps HC, Dohnalová L, Cramer Z, Tian Y, Yueh B, Eskiocak O, Egervari G, Lan Y, Liu J, Fan J, Kim J, Madhu B, Schneider KM, Khoziainova S, Andreeva N, Wang Q, Li N, Furth EE, Bailis W, Kelsen JR, Hamilton KE, Kaestner KH, Berger SL, Epstein JA, Jain R, Li M, Beyaz S, Lengner CJ, Katona BW, Grivennikov SI, Thaiss CA, Levy M. Dmitrieva-Posocco O, et al. Nature. 2022 May;605(7908):160-165. doi: 10.1038/s41586-022-04649-6. Epub 2022 Apr 27. Nature. 2022. PMID: 35477756 Free PMC article.

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