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Randomized Controlled Trial
. 2023 Dec;27(4):699-706.
doi: 10.1007/s10006-022-01104-8. Epub 2022 Aug 3.

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Fabián Pérez-González  1 , Mohammad Abusamak  2 , Luis Miguel Sáez-Alcaide  3 , Jesus Torres García-Denche  3 , Faleh Ahmad Tamimi Marino  4
Affiliations
Randomized Controlled Trial

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Fabián Pérez-González et al. Oral Maxillofac Surg. 2023 Dec.

Abstract

Purpose: To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model.

Methods: Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively.

Results: Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups.

Conclusion: Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.

Keywords: Chronotherapy; Extraction; Ibuprofen; Posology; Third molar.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Postoperative VAS pain measures between treatment and control groups
Fig. 2
Fig. 2
Postoperative swelling repeated measures boxplot between treatment and control groups
Fig. 3
Fig. 3
Postoperative trismus repeated measures boxplot between treatment and control groups
See this image and copyright information in PMC

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References

    1. Neves FS, Souza TC, Almeida SM, Haiter-Neto F, Freitas DQ, Bóscolo FN. Correlation of panoramic radiography and cone beam CT findings in the assessment of the relationship between impacted mandibular third molars and the mandibular canal. Dentomaxillofac Radiol. 2012;41(7):553–557. doi: 10.1259/dmfr/22263461. - DOI - PMC - PubMed
    1. Maglione M, Costantinides F, Bazzocchi G. Classification of impacted mandibular third molars on cone-beam CT images. J Clin Exp Dent. 2015;7(2):e224–e231. doi: 10.4317/jced.51984. - DOI - PMC - PubMed
    1. Martinez-Gonzalez JM, Martinez-Rodriguez N, Ortega Aranegui R, Rubio Alonso LJ, Dientes Retenidos I Normon.
    1. Sağlam AA, Tüzüm MS. Clinical and radiologic investigation of the incidence, complications, and suitable removal times for fully impacted teeth in the Turkish population. Quintessence Int (berlin, Germany: 1985) 2003;34(1):53–59. - PubMed
    1. Donado M, Martinez JM, Cirugia Bucal, Patologia y tecnica 4a edicion Elsevier Masson

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