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. 2022 Jul;17(3):280-285.
doi: 10.17085/apm.22156. Epub 2022 Jul 28.

Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study

Arash Peivandi Yazdi  1 , Mehrdad Esmaeeli  1 , Mehryar Taghavi Gilani  1
Affiliations

Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study

Arash Peivandi Yazdi et al. Anesth Pain Med (Seoul). 2022 Jul.

Abstract

Background: This study aimed to evaluate the postoperative analgesic effect of magnesium sulfate during abdominal surgery.

Methods: This randomized double-blinded study involved 84 patients candidates for abdominal surgery into two same groups. In the magnesium group, at first 25 mg/kg/1 h magnesium sulfate; and then, 100 mg/kg/24 h was infused in the intensive care unit. The pain intensity (the primary outcome), was assessed using the numeric rating scale (NRS) every 3 h. If the NRS was > 3, morphine (as a secondary outcome) was used and evaluated. The results were analyzed using SPSS ver. 19 software, and statistical significance was set at P < 0.05.

Results: Demographic parameters were similar between the groups. The pain intensity were similar at first and then at the third hour in both groups (P = 0.393 and P = 0.172, respectively), but thereafter between 6 and 24 h, the pain severity was significantly lower in the magnesium group (4.4 ± 1.3 in the control and 3.34 ± 1 in the magnesium group at 6th hour and P = 0.001). In addition, morphine intake in the first 24 h in the two groups had a significant difference, with 13.2 ± 5.7 mg in control group and 8 ± 3.5 mg in magnesium group (P = 0.001).

Conclusions: In this study, intravenous magnesium sulfate after abdominal surgeries for 24 h resolved the pain intensity after six hours and reduced morphine dosage.

Keywords: Magnesium sulfate; Morphine; Opioid; Postoperative pain.

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Conflict of interest statement

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Consort flow diagram.
Fig. 2.
Fig. 2.
Pain intensity on 24 h with numeric rating scale (NRS).
See this image and copyright information in PMC

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