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Review
. 2022 Jul 12:2022:2319161.
doi: 10.1155/2022/2319161. eCollection 2022.

Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis

Brehima Diakite  1 , Yaya Kassogue  1 , Mamoudou Maiga  1   2   3 , Guimogo Dolo  1 , Oumar Kassogue  1 , Jonah Musa  2   3   4 , Imran Morhason-Bello  5 , Ban Traore  6 , Cheick Bougadari Traore  1 , Bakarou Kamate  1 , Aissata Coulibaly  1 , Sekou Bah  7 , Sellama Nadifi  8 , Robert Murphy  3 , Jane L Holl  9 , Lifang Hou  2   3
Affiliations
Review

Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis

Brehima Diakite et al. Genet Res (Camb). .

Abstract

A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14-1.49), dominant model (OR = 1.36, 95% CI = 1.09-1.70), and additive model (OR = 1.25, 95% CI = 1.09-1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P < 0.05. The -592C/A polymorphism of the IL-10 gene may be considered a risk factor for cervical cancer.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Flow diagram of eligible studies included.
Figure 2
Figure 2
Forest plots of the association between the -592C/A polymorphism of the IL-10 gene and cervical cancer for the (a) recessive model, (b) dominant model, and (c) additive model. The pooled OR is represented by a black diamond, the OR in each study is represented by blue squares with square sizes inversely proportionate to the standard error of the OR, and the horizontal lines represent the 95% CI.
Figure 3
Figure 3
Forest plots of the association between SNP-592C/A in the IL-10 gene and cervical cancer for the (a) recessive model, (b) dominant model, and (c) additive model in the Caucasian population. The pooled OR is represented by a black diamond, the OR in each study is represented by blue squares with square sizes inversely proportionate to the standard error of the OR, and the horizontal lines represent the 95% CI.
Figure 4
Figure 4
Forest plots of the association between the -592C/A polymorphism of the IL-10 gene and cervical cancer for the (a) recessive model, (b) dominant model, and (c) additive model in the Asian population. The black diamond represents the pooled OR, the blue squares show the OR in each study with square sizes inversely proportional to the standard error of the OR, and the horizontal lines denote the 95% CI.
Figure 5
Figure 5
Funnel plots of the (a) recessive model, (b) dominant model, and (c) additive model precision by OR.
Figure 6
Figure 6
Trial sequential analysis for IL10-592C/A polymorphism under the genotype contrast model. The x-axis shows the number of participants (cases and controls) of the meta-analysis in each branch. The y-axis z-score shows the z-score. The red line represents the required sample size. The green line represents the conventional test boundary (P=0.05).
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