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. 2022 Jun 30;36(2):136-142.
doi: 10.4285/kjt.22.0004. Epub 2022 May 24.

The outcomes of marginal donor hearts compared with ideal donors: a single-center experience in Iran

Behnam Shakerian  1 , Sanaz Dehghani  2   3 , Haleh Ashraf  4 , Shahrokh Karbalai  5 , Abbas Soleimani  5 , Atieh Rezaeefar  5 , Zahra Shajari  5 , Hamidreza Hekmat  6 , Marzieh Latifi  2 , Azadeh Sadatnaseri  5
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The outcomes of marginal donor hearts compared with ideal donors: a single-center experience in Iran

Behnam Shakerian et al. Korean J Transplant. .

Abstract

Background: Heart transplantation has been considered the gold-standard treatment for patients with end-stage heart failure. This study assessed the survival outcomes of marginal donor hearts compared with ideal donor hearts in Iran.

Methods: This retrospective study is based on the follow-up data of heart donors and recipients in the Sina Hospital Organ Procurement Unit. Among the 93 participants, 75 were categorized as ideal donors (group A) and 18 as marginal donors (group B). Group C included heart recipients who received a standard organ, and group D included heart recipients who received a marginal one. To analyze differences in patient characteristics among the groups, posttransplant heart survival was assessed in all groups. All data were obtained from the hospital records.

Results: The mean age of the donors was 26.27±11.44 years (median age, 28 years). The marginal age showed a significant association with donor age. The age of recipients had a significant effect on survival days in the ideal group. Most patients survived for at least 1 year, with a median of 645 days in recipients from marginal donors and 689 days in recipients from ideal donors.

Conclusions: Considering the lack of organ availability in Iran, it may be possible to use marginal donors for marginal recipients, therefore reducing the number of people on the waitlist. We also recommend establishing a national marginal donor system specifically for Iranian patients to extend the donor pool.

Keywords: Graft survival; Heart transplantation; Organ donation; Organ transplantation.

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Fig. 1
Flowchart of study population selection.
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