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. 2020 Apr 8;12(1):25-29.
doi: 10.34172/japid.2020.001. eCollection 2020.

Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells

Simin Sharifi  1 , Mohammad Samiei  2   3 , Elaheh Dalir Abdolahinia  4 , Rovshan Khalilov  5   6   7 , Shahriar Shahi  1   2 , Solmaz Maleki Dizaj  1
Affiliations

Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells

Simin Sharifi et al. J Adv Periodontol Implant Dent. .

Abstract

Background: Periodontitis can lead to progressive destruction of periodontal tissues supporting the tooth. Developing biomaterials for tissue engineering has noticeably improved the existing treatment options. The present study investigated the gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR).

Methods: The scaffolds were prepared through electrospinning technique, and then the physicochemical properties and the cytotoxic effects on dental-derived mesenchymal stem cells were assessed.

Results: The nano-scaffolds were successfully prepared with a mono-dispersed nano-scale diameter (102±0.10 nm), negative surface charge (-20±0.17 mV), and uniform network-shaped morphology. The mesenchymal stem cells derived from the human dental pulp stem cells (hDPSC) with gelatin-hydroxyapatite nano-fibers showed that the prepared scaffolds had a significant proliferative effect. Besides, the applied method can be used to prepare fiber-based structures via other polymeric materials.

Conclusion: The incorporation of different materials to decrease the degradation rate of the fibers can match the speed of tissue regeneration. In this case, the prepared nano-fibers can be applied as a membrane biomaterial.

Keywords: GTR; Gelatin; Hydroxyapatite; Nano-scaffolds; Stem cell.

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Conflict of interest statement

The authors declare no conflict(s) of interest related to the publication of this work.

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