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. 2022 Jul 4;19(7):1198-1204.
doi: 10.7150/ijms.74751. eCollection 2022.

Cytoplasmic IGF2BP2 Protein Expression in Human Patients with Oral Squamous Cell Carcinoma: Prognostic and Clinical Implications

Shu-Hui Lin  1   2 , Chiao-Wen Lin  3   4 , Jeng-Wei Lu  5 , Wei-En Yang  6   7 , Yueh-Min Lin  1   8 , Hsueh-Ju Lu  8   9 , Shun-Fa Yang  6   7
Affiliations

Cytoplasmic IGF2BP2 Protein Expression in Human Patients with Oral Squamous Cell Carcinoma: Prognostic and Clinical Implications

Shu-Hui Lin et al. Int J Med Sci. .

Abstract

Oral squamous cell carcinoma (OSCC) is particularly prevalent in Taiwan. The goal of this study was to determine the clinicopathological role of insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) proteins as an indicator of clinical outcomes in OSCC patients. In this study, immunohistochemical (IHC) analysis was used to examine IGF2BP2 protein expression in 244 OSCC patients. We investigated the relationships among IGF2BP2 expression, clinicopathological variables, and patient survival. Our results showed that IGF2BP2 cytoplasmic protein expression was significantly correlated with lymph node metastasis, cancer stage, and patient survival. Kaplan-Meier survival curves revealed that elevated cytoplasmic IGF2BP2 expression levels in OSCC patients were associated with poor overall survival. Moreover, multivariate cox proportional hazard models revealed that cytoplasmic IGF2BP2 expression, T status, and lymph node metastasis were independent prognostic factors for survival. In conclusion, IGF2BP2 protein was found to be a helpful predictive marker for OSCC patients, as well as a possible therapeutic target for OSCC treatment.

Keywords: IGF2BP2; immunohistochemistry; oral squamous cell carcinoma; survival; tissue microarray.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
IHC analysis of cytoplasmic IGF2BP2 expression in human OSCC tissue showing negative (A and D), positive (B and E), and strong positive expression (C and F). Magnification: (top panel) 100x and lower panel (200x). Scale bars=25 and 50 µm.
Figure 2
Figure 2
Relationship between cytoplasmic IGF2BP2 expression levels and overall survival in patients with OSCC based on the Kaplan-Meier method. Analysis was based on included 244 oral squamous cell carcinoma samples, using Kaplan-Meier analysis in conjunction with the log-rank test to establish survival curves.
See this image and copyright information in PMC

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